Seroatlas · Human Serome Atlas

RNF7

RING-box protein 2

Also known as: CKBBP1, RBX2, RBX2_HUMAN, ROC2, SAG

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UBF6
Gene
RNF7
Ensembl
ENSG00000114125
Chromosome
3
Canonical length
113 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a highly conserved ring finger protein. It is an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for cell cycle progression and signal transduction. This protein interacts with, and is a substrate of, casein kinase II (CSNK2A1/CKII). The phosphorylation of this protein by CSNK2A1 has been shown to promote the degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27Kip1(CDKN1B). Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

113 residues, UniProt reviewed canonical sequence.

>Q9UBF6|RNF7
     1  MADVEDGEET CALASHSGSS GSKSGGDKMF SLKKWNAVAM WSWDVECDTC AICRVQVMDA
    61  CLRCQAENKQ EDCVVVWGEC NHSFHNCCMS LWVKQNNRCP LCQQDWVVQR IGK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RNF7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.49
Highest tissue expression
139 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 139 nTPM
  • adrenal gland: 111 nTPM
  • tongue: 105 nTPM
  • choroid plexus: 103 nTPM
  • heart muscle: 98 nTPM
  • blood vessel: 95 nTPM

Single-cell type

  • late spermatids: 73 nCPM
  • early spermatids: 43 nCPM
  • tuft cells: 23 nCPM
  • papillary tip epithelial cells: 21 nCPM
  • parietal cells: 19 nCPM
  • megakaryocytes: 19 nCPM

Immune cell

  • classical monocyte: 129 nTPM
  • non-classical monocyte: 126 nTPM
  • total PBMC: 122 nTPM
  • basophil: 120 nTPM
  • intermediate monocyte: 117 nTPM
  • myeloid DC: 113 nTPM

Brain region

  • choroid plexus: 46 nTPM
  • hypothalamus: 36 nTPM
  • thalamus: 34 nTPM
  • pons: 33 nTPM
  • white matter: 32 nTPM
  • basal ganglia: 32 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RNF7.

Disease | AutoantibodyPubMed

Conditions in which antibodies against RNF7 are reported. Each links to that disease's full target list.

ReferencesPubMed · IEDB

Publications for RNF7 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Reference: AutoantibodyPubMed

8 publications

Show 3 more

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.25
gnomAD pLI
0.03
gnomAD missense Z
1.56
DepMap mean gene effect
0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RNF7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RNF7 as an antibody target. Whether an autoantibody or antibody against RNF7 could matter depends on whether native RNF7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RNF7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RNF7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RNF7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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