Seroatlas · Human Serome Atlas

ASB12

Ankyrin repeat and SOCS box protein 12

Also known as: ASB12_HUMAN, FLJ39577

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8WXK4
Gene: ASB12
Ensembl: ENSG00000198881
Chromosome: X
Canonical length: 309 aa
Protein class: Metabolic proteins, Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and a SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. [provided by RefSeq, Jan 2011]

Canonical amino-acid sequenceUniProt

309 residues, UniProt reviewed canonical sequence.

>Q8WXK4|ASB12
     1  MNLMDITKIF SLLQPDKEEE DTDTEEKQAL NQAVYDNDSY TLDQLLRQER YKRFINSRSG
    61  WGVPGTPLRL AASYGHLSCL QVLLAHGADV DSLDVKAQTP LFTAVSHGHL DCVRVLLEAG
   121  ASPGGSIYNN CSPVLTAARD GAVAILQELL DHGAEANVKA KLPVWASNIA SCSGPLYLAA
   181  VYGHLDCFRL LLLHGADPDY NCTDQGLLAR VPRPRTLLEI CLHHNCEPEY IQLLIDFGAN
   241  IYLPSLSLDL TSQDDKGIAL LLQARATPRS LLSQVRLVVR RALCQAGQPQ AINQLDIPPM
   301  LISYLKHQL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ASB12 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 85 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 85 nTPM
tongue: 49 nTPM
heart muscle: 3.3 nTPM
testis: 1.6 nTPM
fallopian tube: 1.3 nTPM
blood vessel: 0.9 nTPM

Single-cell type

late spermatids: 40 nCPM
early spermatids: 6.9 nCPM
myonuclei: 5.1 nCPM
cone photoreceptor cells: 2.1 nCPM
thymocytes: 1.7 nCPM
thymic myoid cells: 1.4 nCPM

Immune cell

basophil: 1.1 nTPM
T-reg: 0.3 nTPM
naive B-cell: 0.2 nTPM
MAIT T-cell: 0.1 nTPM
memory CD4 T-cell: 0.1 nTPM
total PBMC: 0.1 nTPM

Brain region

midbrain: 0.5 nTPM
cerebral cortex: 0.4 nTPM
amygdala: 0.3 nTPM
basal ganglia: 0.3 nTPM
cerebellum: 0.3 nTPM
choroid plexus: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.68
gnomAD pLI: 0
gnomAD missense Z: -0.93
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

protein ubiquitination

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ASB12 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ASB12 as an antibody target. Whether an autoantibody or antibody against ASB12 could matter depends on whether native ASB12 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ASB12 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ASB12 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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