Seroatlas · Human Serome Atlas

ARIH2

E3 ubiquitin-protein ligase ARIH2

Also known as: ARI2_HUMAN, TRIAD1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O95376
Gene
ARIH2
Ensembl
ENSG00000177479
Chromosome
3
Canonical length
493 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

The protein encoded by this gene is an E3 ubiquitin-protein ligase that polyubiquitinates some proteins, tagging them for degradation. The encoded protein upregulates p53 in some cancer cells and may inhibit myelopoiesis. Several transcript variants encoding different isoforms have been found for this gene, although the full-length nature of some of them have not been determined yet. [provided by RefSeq, Nov 2015]

Canonical amino-acid sequenceUniProt

493 residues, UniProt reviewed canonical sequence.

>O95376|ARIH2
     1  MSVDMNSQGS DSNEEDYDPN CEEEEEEEED DPGDIEDYYV GVASDVEQQG ADAFDPEEYQ
    61  FTCLTYKESE GALNEHMTSL ASVLKVSHSV AKLILVNFHW QVSEILDRYK SNSAQLLVEA
   121  RVQPNPSKHV PTSHPPHHCA VCMQFVRKEN LLSLACQHQF CRSCWEQHCS VLVKDGVGVG
   181  VSCMAQDCPL RTPEDFVFPL LPNEELREKY RRYLFRDYVE SHYQLQLCPG ADCPMVIRVQ
   241  EPRARRVQCN RCNEVFCFKC RQMYHAPTDC ATIRKWLTKC ADDSETANYI SAHTKDCPKC
   301  NICIEKNGGC NHMQCSKCKH DFCWMCLGDW KTHGSEYYEC SRYKENPDIV NQSQQAQARE
   361  ALKKYLFYFE RWENHNKSLQ LEAQTYQRIH EKIQERVMNN LGTWIDWQYL QNAAKLLAKC
   421  RYTLQYTYPY AYYMESGPRK KLFEYQQAQL EAEIENLSWK VERADSYDRG DLENQMHIAE
   481  QRRRTLLKDF HDT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARIH2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
94 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 94 nTPM
  • tongue: 74 nTPM
  • heart muscle: 51 nTPM
  • choroid plexus: 32 nTPM
  • epididymis: 32 nTPM
  • retina: 30 nTPM

Single-cell type

  • myonuclei: 299 nCPM
  • early primary spermatocytes: 251 nCPM
  • cardiomyocytes: 222 nCPM
  • oligodendrocytes: 150 nCPM
  • rod photoreceptor cells: 148 nCPM
  • adrenal cortex cells: 146 nCPM

Immune cell

  • basophil: 53 nTPM
  • gdT-cell: 44 nTPM
  • eosinophil: 40 nTPM
  • total PBMC: 39 nTPM
  • naive CD8 T-cell: 38 nTPM
  • memory CD8 T-cell: 37 nTPM

Brain region

  • white matter: 33 nTPM
  • choroid plexus: 28 nTPM
  • basal ganglia: 27 nTPM
  • cerebellum: 27 nTPM
  • pons: 26 nTPM
  • cerebral cortex: 25 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ARIH2.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 62 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.28
gnomAD pLI
0.99
gnomAD missense Z
3.58
DepMap mean gene effect
0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ARIH2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARIH2 as an antibody target. Whether an autoantibody or antibody against ARIH2 could matter depends on whether native ARIH2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARIH2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ARIH2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ARIH2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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