DCUN1D2
DCN1-like protein 2
Also known as: C13orf17, DCNL2_HUMAN, FLJ10704, FLJ20092
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q6PH85
- Gene
- DCUN1D2
- Ensembl
- ENSG00000150401
- Chromosome
- 13
- Canonical length
- 259 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Plasma membrane,Cytosol
OverviewNCBI Gene
Enables cullin family protein binding activity. Involved in positive regulation of protein neddylation. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
259 residues, UniProt reviewed canonical sequence.
>Q6PH85|DCUN1D2
1 MHKLKSSQKD KVRQFMACTQ AGERTAIYCL TQNEWRLDEA TDSFFQNPDS LHRESMRNAV
61 DKKKLERLYG RYKDPQDENK IGVDGIQQFC DDLSLDPASI SVLVIAWKFR AATQCEFSRK
121 EFLDGMTELG CDSMEKLKAL LPRLEQELKD TAKFKDFYQF TFTFAKNPGQ KGLDLEMAVA
181 YWKLVLSGRF KFLDLWNTFL MEHHKRSIPR DTWNLLLDFG NMIADDMSNY DEEGAWPVLI
241 DDFVEYARPV VTGGKRSLFLocalizationUniProt · AlphaFold · HPA
Whether an antibody against DCUN1D2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.3
- Highest tissue expression
- 102 nTPM
Expression across tissuesHPA
Tissue
- skeletal muscle: 102 nTPM
- heart muscle: 92 nTPM
- tongue: 64 nTPM
- cerebellum: 39 nTPM
- choroid plexus: 21 nTPM
- retina: 16 nTPM
Single-cell type
- choroid plexus epithelial cells: 155 nCPM
- sertoli cells: 101 nCPM
- myonuclei: 80 nCPM
- podocytes: 79 nCPM
- retinal horizontal cells: 78 nCPM
- neutrophils: 75 nCPM
Immune cell
- basophil: 11 nTPM
- MAIT T-cell: 2.5 nTPM
- eosinophil: 2.2 nTPM
- gdT-cell: 2 nTPM
- T-reg: 2 nTPM
- memory B-cell: 1.9 nTPM
Brain region
- choroid plexus: 73 nTPM
- cerebellum: 57 nTPM
- white matter: 40 nTPM
- cerebral cortex: 39 nTPM
- pons: 37 nTPM
- medulla oblongata: 33 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.51
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.12
- DepMap mean gene effect
- 0.02
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of DCUN1D2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads DCUN1D2 as an antibody target. Whether an autoantibody or antibody against DCUN1D2 could matter depends on whether native DCUN1D2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
DCUN1D2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label DCUN1D2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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