Seroatlas · Human Serome Atlas

ASB6

Ankyrin repeat and SOCS box protein 6

Also known as: ASB6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NWX5
Gene: ASB6
Ensembl: ENSG00000148331
Chromosome: 9
Canonical length: 421 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene belongs to a family of ankyrin repeat proteins that, along with four other protein families, contain a C-terminal SOCS box motif. Growing evidence suggests that the SOCS box, similar to the F-box, acts as a bridge between specific substrate-binding domains and the more generic proteins that comprise a large family of E3 ubiquitin protein ligases. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jan 2011]

Canonical amino-acid sequenceUniProt

421 residues, UniProt reviewed canonical sequence.

>Q9NWX5|ASB6
     1  MPFLHGFRRI IFEYQPLVDA ILGSLGIQDP ERQESLDRPS YVASEESRIL VLTELLERKA
    61  HSPFYQEGVS NALLKMAELG LTRAADVLLR HGANLNFEDP VTYYTALHIA VLRNQPDMVE
   121  LLVHHGADVN RRDRIHESSP LDLASEEPER LPCLQRLLDL GADVNAADKH GKTALLHALA
   181  SSDGVQIHNT ENIRLLLEGG ADVKATTKDG DTVFTCIIFL LGETVGGDKE EAQMINRFCF
   241  QVTRLLLAHG ADPSECPAHE SLTHICLKSF KLHFPLLRFL LESGAAYNCS LHGASCWSGF
   301  HIIFERLCSH PGCTEDESHA DLLRKAETVL DLMVTNSQKL QLPENFDIHP VGSLAEKIQA
   361  LHFSLRQLES YPPPLKHLCR VAIRLYLQPW PVDVKVKALP LPDRLKWYLL SEHSGSVEDD
   421  I

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ASB6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 25 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 25 nTPM
cerebral cortex: 22 nTPM
cerebellum: 21 nTPM
adrenal gland: 19 nTPM
skin: 19 nTPM
spleen: 17 nTPM

Single-cell type

oocytes: 60 nCPM
basal keratinocytes: 28 nCPM
suprabasal keratinocytes: 26 nCPM
tuft cells: 23 nCPM
epicardial cells: 23 nCPM
retinal pigment epithelial cells: 21 nCPM

Immune cell

NK-cell: 11 nTPM
gdT-cell: 11 nTPM
memory CD8 T-cell: 10 nTPM
MAIT T-cell: 9.4 nTPM
T-reg: 8.9 nTPM
naive CD4 T-cell: 8.6 nTPM

Brain region

cerebral cortex: 30 nTPM
medulla oblongata: 29 nTPM
hippocampal formation: 29 nTPM
choroid plexus: 28 nTPM
amygdala: 27 nTPM
basal ganglia: 26 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.97
gnomAD pLI: 0
gnomAD missense Z: 1.05
DepMap mean gene effect: -0.23
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

cytosol

Protein domainsUniProt · Pfam · InterPro

SOCS box domain
Ankyrin repeat
SOCS box-like domain superfamily
Ankyrin repeat-containing domain superfamily
SOCS box
Ankyrin repeats (3 copies)
Ankyrin repeats (many copies)
Ankyrin repeat and SOCS box protein 6, SOCS box domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ASB6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ASB6 as an antibody target. Whether an autoantibody or antibody against ASB6 could matter depends on whether native ASB6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ASB6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ASB6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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