Seroatlas · Human Serome Atlas

COMMD3

COMM domain-containing protein 3

Also known as: BUP, C10orf8, COMD3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UBI1
Gene: COMMD3
Ensembl: ENSG00000148444
Chromosome: 10
Canonical length: 195 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be involved in sodium ion transport. Predicted to be located in extracellular region and ficolin-1-rich granule lumen. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

195 residues, UniProt reviewed canonical sequence.

>Q9UBI1|COMMD3
     1  MELSESVQKG FQMLADPRSF DSNAFTLLLR AAFQSLLDAQ ADEAVLDHPD LKHIDPVVLK
    61  HCHAAAATYI LEAGKHRADK STLSTYLEDC KFDRERIELF CTEYQNNKNS LEILLGSIGR
   121  SLPHITDVSW RLEYQIKTNQ LHRMYRPAYL VTLSVQNTDS PSYPEISFSC SMEQLQDLVG
   181  KLKDASKSLE RATQL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against COMMD3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 81 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 81 nTPM
heart muscle: 75 nTPM
tongue: 71 nTPM
liver: 59 nTPM
thymus: 57 nTPM
pancreas: 55 nTPM

Single-cell type

early spermatids: 290 nCPM
late primary spermatocytes: 82 nCPM
late spermatids: 67 nCPM
parietal cells: 55 nCPM
oligodendrocytes: 44 nCPM
gastric chief cells: 43 nCPM

Immune cell

basophil: 155 nTPM
plasmacytoid DC: 141 nTPM
total PBMC: 118 nTPM
myeloid DC: 118 nTPM
classical monocyte: 98 nTPM
intermediate monocyte: 98 nTPM

Brain region

white matter: 32 nTPM
spinal cord: 24 nTPM
cerebellum: 23 nTPM
medulla oblongata: 23 nTPM
hypothalamus: 21 nTPM
basal ganglia: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.14
gnomAD pLI: 0
gnomAD missense Z: -0.35
DepMap mean gene effect: -0.18
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

sodium ion transport

Cellular components

Protein domainsUniProt · Pfam · InterPro

COMM domain
COMM domain
COMMD2-7/10, HN domain
COMM domain-containing protein 3

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of COMMD3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads COMMD3 as an antibody target. Whether an autoantibody or antibody against COMMD3 could matter depends on whether native COMMD3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

COMMD3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label COMMD3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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