Seroatlas · Human Serome Atlas

ASB8

Ankyrin repeat and SOCS box protein 8

Also known as: ASB8_HUMAN, FLJ21255, MGC5540

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H765
Gene: ASB8
Ensembl: ENSG00000177981
Chromosome: 12
Canonical length: 288 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be involved in intracellular signal transduction and protein ubiquitination. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

288 residues, UniProt reviewed canonical sequence.

>Q9H765|ASB8
     1  MSSSMWYIMQ SIQSKYSLSE RLIRTIAAIR SFPHDNVEDL IRGGADVNCT HGTLKPLHCA
    61  CMVSDADCVE LLLEKGAEVN ALDGYNRTAL HYAAEKDEAC VEVLLEYGAN PNALDGNRDT
   121  PLHWAAFKNN AECVRALLES GASVNALDYN NDTPLSWAAM KGNLESVSIL LDYGAEVRVI
   181  NLIGQTPISR LVALLVRGLG TEKEDSCFEL LHRAVGHFEL RKNGTMPREV ARDPQLCEKL
   241  TVLCSAPGTL KTLARYAVRR SLGLQYLPDA VKGLPLPASL KEYLLLLE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ASB8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 274 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 274 nTPM
tongue: 173 nTPM
retina: 68 nTPM
bone marrow: 58 nTPM
heart muscle: 43 nTPM
parathyroid gland: 31 nTPM

Single-cell type

thymic myoid cells: 461 nCPM
platelets: 202 nCPM
myonuclei: 144 nCPM
late spermatids: 134 nCPM
oocytes: 101 nCPM
rod photoreceptor cells: 96 nCPM

Immune cell

eosinophil: 117 nTPM
basophil: 92 nTPM
neutrophil: 53 nTPM
NK-cell: 37 nTPM
non-classical monocyte: 36 nTPM
naive CD8 T-cell: 34 nTPM

Brain region

cerebellum: 71 nTPM
white matter: 48 nTPM
cerebral cortex: 46 nTPM
pons: 46 nTPM
hypothalamus: 45 nTPM
basal ganglia: 45 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.33
gnomAD pLI: 0
gnomAD missense Z: 1.31
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

cytosol

Protein domainsUniProt · Pfam · InterPro

SOCS box domain
Ankyrin repeat
SOCS box-like domain superfamily
Ankyrin repeat-containing domain superfamily
SOCS box
Ankyrin repeats (3 copies)
Ankyrin repeats (many copies)
Ankyrin repeat and SOCS box protein 8, SOCS box domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ASB8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ASB8 as an antibody target. Whether an autoantibody or antibody against ASB8 could matter depends on whether native ASB8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ASB8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ASB8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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