Seroatlas · Human Serome Atlas

DCUN1D3

DCN1-like protein 3

Also known as: DCNL3_HUMAN, DKFZp686O0290, FLJ41725, MGC48972, SCCRO3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IWE4
Gene: DCUN1D3
Ensembl: ENSG00000188215
Chromosome: 16
Canonical length: 304 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Enables cullin family protein binding activity. Involved in several processes, including negative regulation of G1/S transition of mitotic cell cycle; regulation of protein neddylation; and response to UV-C. Located in several cellular components, including cytosol; nucleoplasm; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

304 residues, UniProt reviewed canonical sequence.

>Q8IWE4|DCUN1D3
     1  MGQCVTKCKN PSSTLGSKNG DREPSNKSHS RRGAGHREEQ VPPCGKPGGD ILVNGTKKAE
    61  AATEACQLPT SSGDAGRESK SNAEESSLQR LEELFRRYKD EREDAILEEG MERFCNDLCV
   121  DPTEFRVLLL AWKFQAATMC KFTRKEFFDG CKAISADSID GICARFPSLL TEAKQEDKFK
   181  DLYRFTFQFG LDSEEGQRSL HREIAIALWK LVFTQNNPPV LDQWLNFLTE NPSGIKGISR
   241  DTWNMFLNFT QVIGPDLSNY SEDEAWPSLF DTFVEWEMER RKREGEGRGA LSSGPEGLCP
   301  EEQT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DCUN1D3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 27 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 27 nTPM
adipose tissue: 19 nTPM
retina: 12 nTPM
liver: 11 nTPM
blood vessel: 9.9 nTPM
lung: 9.2 nTPM

Single-cell type

paneth cells: 3.9 nCPM
medullary thymic epithelial cells: 2.4 nCPM
platelets: 1.4 nCPM
urothelial cells: 1.4 nCPM
ocular epithelial cells: 1.3 nCPM
early spermatids: 1.2 nCPM

Immune cell

basophil: 1.3 nTPM
intermediate monocyte: 0.6 nTPM
memory CD8 T-cell: 0.6 nTPM
naive CD8 T-cell: 0.6 nTPM
NK-cell: 0.6 nTPM
non-classical monocyte: 0.5 nTPM

Brain region

white matter: 19 nTPM
cerebellum: 16 nTPM
thalamus: 15 nTPM
hypothalamus: 14 nTPM
cerebral cortex: 14 nTPM
midbrain: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.43
gnomAD pLI: 0.87
gnomAD missense Z: 1.4
DepMap mean gene effect: 0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DCUN1D3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DCUN1D3 as an antibody target. Whether an autoantibody or antibody against DCUN1D3 could matter depends on whether native DCUN1D3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DCUN1D3 is annotated at the cell surface, where native DCUN1D3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label DCUN1D3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...