Seroatlas · Human Serome Atlas

ASB1

Ankyrin repeat and SOCS box protein 1

Also known as: ASB-1, ASB1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9Y576
Gene
ASB1
Ensembl
ENSG00000065802
Chromosome
2
Canonical length
335 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

The protein encoded by this gene contains an ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, targeting them for ubiquitination and degradation. [provided by RefSeq, Aug 2016]

Canonical amino-acid sequenceUniProt

335 residues, UniProt reviewed canonical sequence.

>Q9Y576|ASB1
     1  MAEGGSPDGR AGPGSAGRNL KEWLREQFCD HPLEHCEDTR LHDAAYVGDL QTLRSLLQEE
    61  SYRSRINEKS VWCCGWLPCT PLRIAATAGH GSCVDFLIRK GAEVDLVDVK GQTALYVAVV
   121  NGHLESTQIL LEAGADPNGS RHHRSTPVYH ASRVGRADIL KALIRYGADV DVNHHLTPDV
   181  QPRFSRRLTS LVVCPLYISA AYHNLQCFRL LLLAGANPDF NCNGPVNTQG FYRGSPGCVM
   241  DAVLRHGCEA AFVSLLVEFG ANLNLVKWES LGPESRGRRK VDPEALQVFK EARSVPRTLL
   301  CLCRVAVRRA LGKHRLHLIP SLPLPDPIKK FLLHE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ASB1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
22 nTPM

Expression across tissuesHPA

Tissue

  • tongue: 22 nTPM
  • skeletal muscle: 20 nTPM
  • spinal cord: 20 nTPM
  • midbrain: 18 nTPM
  • amygdala: 16 nTPM
  • basal ganglia: 16 nTPM

Single-cell type

  • late primary spermatocytes: 62 nCPM
  • cardiomyocytes: 53 nCPM
  • differentiating spermatogonia: 44 nCPM
  • early primary spermatocytes: 38 nCPM
  • extravillous trophoblasts: 38 nCPM
  • epicardial cells: 36 nCPM

Immune cell

  • memory B-cell: 4.3 nTPM
  • gdT-cell: 4.2 nTPM
  • memory CD8 T-cell: 4.1 nTPM
  • T-reg: 4.1 nTPM
  • memory CD4 T-cell: 3 nTPM
  • naive CD8 T-cell: 3 nTPM

Brain region

  • midbrain: 37 nTPM
  • pons: 35 nTPM
  • spinal cord: 34 nTPM
  • hypothalamus: 34 nTPM
  • amygdala: 34 nTPM
  • thalamus: 33 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.94
gnomAD pLI
0
gnomAD missense Z
1.27
DepMap mean gene effect
0.05
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ASB1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ASB1 as an antibody target. Whether an autoantibody or antibody against ASB1 could matter depends on whether native ASB1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ASB1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ASB1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ASB1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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