DCUN1D4
DCN1-like protein 4
Also known as: DCNL4_HUMAN, KIAA0276
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q92564
- Gene
- DCUN1D4
- Ensembl
- ENSG00000109184
- Chromosome
- 4
- Canonical length
- 292 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Vesicles
OverviewNCBI Gene
Enables cullin family protein binding activity. Involved in positive regulation of protein neddylation. Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
292 residues, UniProt reviewed canonical sequence.
>Q92564|DCUN1D4
1 MHSDAAAVNF QLNSHLSTLA NIHKIYHTLN KLNLTEDIGQ DDHQTGSLRS CSSSDCFNKV
61 MPPRKKRRPA SGDDLSAKKS RHDSMYRKYD STRIKTEEEA FSSKRCLEWF YEYAGTDDVV
121 GPEGMEKFCE DIGVEPENVV MLVLAWKLDA QNMGYFTLQE WLKGMTSLQC DTTEKLRNTL
181 DYLRSFLNDS TNFKLIYRYA FDFAREKDQR SLDINTAKCM LGLLLGKIWP LFPVFHQFLE
241 QSKYKVINKD QWCNVLEFSR TINLDLSNYD EDGAWPVLLD EFVEWYKDKQ MSLocalizationUniProt · AlphaFold · HPA
Whether an antibody against DCUN1D4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.38
- Highest tissue expression
- 27 nTPM
Expression across tissuesHPA
Tissue
- liver: 27 nTPM
- hypothalamus: 18 nTPM
- blood vessel: 18 nTPM
- adrenal gland: 17 nTPM
- urinary bladder: 17 nTPM
- smooth muscle: 16 nTPM
Single-cell type
- corticotrophs: 230 nCPM
- pituicytes/fscs: 202 nCPM
- adrenal cortex cells: 199 nCPM
- late spermatids: 191 nCPM
- pituitary stem cells: 152 nCPM
- sertoli cells: 151 nCPM
Immune cell
- eosinophil: 8.8 nTPM
- MAIT T-cell: 8.6 nTPM
- basophil: 6.8 nTPM
- naive CD8 T-cell: 6.8 nTPM
- memory CD8 T-cell: 6.5 nTPM
- memory CD4 T-cell: 6.4 nTPM
Brain region
- thalamus: 33 nTPM
- cerebral cortex: 31 nTPM
- pons: 29 nTPM
- hypothalamus: 29 nTPM
- midbrain: 27 nTPM
- white matter: 27 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.59
- gnomAD pLI
- 0.05
- gnomAD missense Z
- 0.68
- DepMap mean gene effect
- 0
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of DCUN1D4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads DCUN1D4 as an antibody target. Whether an autoantibody or antibody against DCUN1D4 could matter depends on whether native DCUN1D4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
DCUN1D4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label DCUN1D4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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