Seroatlas · Human Serome Atlas

COMMD4

COMM domain-containing protein 4

Also known as: COMD4_HUMAN, FLJ20452

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H0A8
Gene: COMMD4
Ensembl: ENSG00000140365
Chromosome: 15
Canonical length: 199 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles,Plasma membrane,Cytosol

OverviewNCBI Gene

Predicted to be involved in signal transduction. Located in cytosol; intracellular membrane-bounded organelle; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

199 residues, UniProt reviewed canonical sequence.

>Q9H0A8|COMMD4
     1  MRFRFCGDLD CPDWVLAEIS TLAKMSSVKL RLLCSQVLKE LLGQGIDYEK ILKLTADAKF
    61  ESGDVKATVA VLSFILSSAA KHSVDGESLS SELQQLGLPK EHAASLCRCY EEKQSPLQKH
   121  LRVCSLRMNR LAGVGWRVDY TLSSSLLQSV EEPMVHLRLE VAAAPGTPAQ PVAMSLSADK
   181  FQVLLAELKQ AQTLMSSLG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against COMMD4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 96 nTPM

Expression across tissuesHPA

Tissue

testis: 96 nTPM
adrenal gland: 95 nTPM
choroid plexus: 84 nTPM
kidney: 79 nTPM
liver: 71 nTPM
stomach: 53 nTPM

Single-cell type

hofbauer cells: 181 nCPM
late primary spermatocytes: 166 nCPM
extravillous trophoblasts: 121 nCPM
migrating cytotrophoblasts: 104 nCPM
esophageal basal cells: 99 nCPM
megakaryocytes: 99 nCPM

Immune cell

T-reg: 88 nTPM
gdT-cell: 85 nTPM
NK-cell: 78 nTPM
plasmacytoid DC: 71 nTPM
memory CD8 T-cell: 64 nTPM
intermediate monocyte: 62 nTPM

Brain region

choroid plexus: 25 nTPM
thalamus: 25 nTPM
white matter: 22 nTPM
spinal cord: 19 nTPM
cerebellum: 18 nTPM
hypothalamus: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.15
gnomAD pLI: 0
gnomAD missense Z: -0.07
DepMap mean gene effect: -0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

signal transduction

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of COMMD4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads COMMD4 as an antibody target. Whether an autoantibody or antibody against COMMD4 could matter depends on whether native COMMD4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

COMMD4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label COMMD4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...