Seroatlas · Human Serome Atlas

COPS7B

COP9 signalosome complex subunit 7b

Also known as: CSN7B, CSN7B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H9Q2
Gene: COPS7B
Ensembl: ENSG00000144524
Chromosome: 2
Canonical length: 264 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Involved in protein deneddylation. Located in nucleoplasm. Part of COP9 signalosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

264 residues, UniProt reviewed canonical sequence.

>Q9H9Q2|COPS7B
     1  MAGEQKPSSN LLEQFILLAK GTSGSALTAL ISQVLEAPGV YVFGELLELA NVQELAEGAN
    61  AAYLQLLNLF AYGTYPDYIA NKESLPELST AQQNKLKHLT IVSLASRMKC IPYSVLLKDL
   121  EMRNLRELED LIIEAVYTDI IQGKLDQRNQ LLEVDFCIGR DIRKKDINNI VKTLHEWCDG
   181  CEAVLLGIEQ QVLRANQYKE NHNRTQQQVE AEVTNIKKTL KATASSSAQE MEQQLAEREC
   241  PPHAEQRQPT KKMSKVKGLV SSRH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against COPS7B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 21 nTPM

Expression across tissuesHPA

Tissue

thymus: 21 nTPM
tonsil: 21 nTPM
testis: 19 nTPM
parathyroid gland: 19 nTPM
spleen: 17 nTPM
lymph node: 17 nTPM

Single-cell type

oocytes: 276 nCPM
differentiating spermatogonia: 76 nCPM
thyrotrophs: 57 nCPM
early spermatids: 57 nCPM
early primary spermatocytes: 56 nCPM
late primary spermatocytes: 50 nCPM

Immune cell

NK-cell: 16 nTPM
non-classical monocyte: 14 nTPM
memory B-cell: 13 nTPM
naive B-cell: 13 nTPM
naive CD4 T-cell: 13 nTPM
basophil: 13 nTPM

Brain region

cerebral cortex: 24 nTPM
white matter: 20 nTPM
basal ganglia: 19 nTPM
midbrain: 19 nTPM
pons: 18 nTPM
thalamus: 18 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.49
gnomAD pLI: 0.6
gnomAD missense Z: 1.09
DepMap mean gene effect: 0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of COPS7B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads COPS7B as an antibody target. Whether an autoantibody or antibody against COPS7B could matter depends on whether native COPS7B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

COPS7B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label COPS7B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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