Seroatlas · Human Serome Atlas

DCUN1D1

DCN1-like protein 1

Also known as: DCNL1_HUMAN, DCUN1L1, RP42, SCCRO, SCRO, Tes3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96GG9
Gene: DCUN1D1
Ensembl: ENSG00000043093
Chromosome: 3
Canonical length: 259 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Enables cullin family protein binding activity. Involved in positive regulation of protein neddylation and regulation of protein ubiquitination. Located in cytosol and nucleoplasm. Part of ubiquitin ligase complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

259 residues, UniProt reviewed canonical sequence.

>Q96GG9|DCUN1D1
     1  MNKLKSSQKD KVRQFMIFTQ SSEKTAVSCL SQNDWKLDVA TDNFFQNPEL YIRESVKGSL
    61  DRKKLEQLYN RYKDPQDENK IGIDGIQQFC DDLALDPASI SVLIIAWKFR AATQCEFSKQ
   121  EFMDGMTELG CDSIEKLKAQ IPKMEQELKE PGRFKDFYQF TFNFAKNPGQ KGLDLEMAIA
   181  YWNLVLNGRF KFLDLWNKFL LEHHKRSIPK DTWNLLLDFS TMIADDMSNY DEEGAWPVLI
   241  DDFVEFARPQ IAGTKSTTV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DCUN1D1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 231 nTPM

Expression across tissuesHPA

Tissue

testis: 231 nTPM
tongue: 36 nTPM
liver: 29 nTPM
skeletal muscle: 29 nTPM
bone marrow: 21 nTPM
kidney: 18 nTPM

Single-cell type

late spermatids: 24,837 nCPM
early spermatids: 2,840 nCPM
late primary spermatocytes: 800 nCPM
thymic myoid cells: 268 nCPM
renal collecting duct principal cells: 149 nCPM
esophageal apical cells: 137 nCPM

Immune cell

eosinophil: 16 nTPM
neutrophil: 14 nTPM
NK-cell: 11 nTPM
basophil: 10 nTPM
myeloid DC: 10 nTPM
intermediate monocyte: 9.2 nTPM

Brain region

white matter: 54 nTPM
cerebral cortex: 47 nTPM
basal ganglia: 46 nTPM
cerebellum: 45 nTPM
pons: 45 nTPM
midbrain: 45 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.28
gnomAD pLI: 0.99
gnomAD missense Z: 1.98
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 16% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DCUN1D1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DCUN1D1 as an antibody target. Whether an autoantibody or antibody against DCUN1D1 could matter depends on whether native DCUN1D1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DCUN1D1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DCUN1D1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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