Seroatlas · Human Serome Atlas

LRRC41

Leucine-rich repeat-containing protein 41

Also known as: LRC41_HUMAN, MUF1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q15345
Gene: LRRC41
Ensembl: ENSG00000132128
Chromosome: 1
Canonical length: 812 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear bodies

OverviewNCBI Gene

Predicted to enable identical protein binding activity. Predicted to be involved in protein ubiquitination. Located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

812 residues, UniProt reviewed canonical sequence.

>Q15345|LRRC41
     1  MAAPEAWRAR SCWFCEVAAA TTMEATSREA APAKSSASGP NAPPALFELC GRAVSAHMGV
    61  LESGVWALPG PILQSILPLL NIYYLERIEE TALKKGLSTQ AIWRRLWDEL MKTRPSSLES
   121  VTCWRAKFME AFFSHVLRGT IDVSSDRRLC DQRFSPLLHS SRHVRQLTIC NMLQGATELV
   181  AEPNRRVLET LASSLHTLKF RHLLFSDVAA QQSLRQLLHQ LIHHGAVSQV SLYSWPVPES
   241  ALFILILTMS AGFWQPGPGG PPCRLCGEAS RGRAPSRDEG SLLLGSRRPR RDAAERCAAA
   301  LMASRRKSEA KQMPRAAPAT RVTRRSTQES LTAGGTDLKR ELHPPATSHE APGTKRSPSA
   361  PAATSSASSS TSSYKRAPAS SAPQPKPLKR FKRAAGKKGA RTRQGPGAES EDLYDFVFIV
   421  AGEKEDGEEM EIGEVACGAL DGSDPSCLGL PALEASQRFR SISTLELFTV PLSTEAALTL
   481  CHLLSSWVSL ESLTLSYNGL GSNIFRLLDS LRALSGQAGC RLRALHLSDL FSPLPILELT
   541  RAIVRALPLL RVLSIRVDHP SQRDNPGVPG NAGPPSHIIG DEEIPENCLE QLEMGFPRGA
   601  QPAPLLCSVL KASGSLQQLS LDSATFASPQ DFGLVLQTLK EYNLALKRLS FHDMNLADCQ
   661  SEVLFLLQNL TLQEITFSFC RLFEKRPAQF LPEMVAAMKG NSTLKGLRLP GNRLGNAGLL
   721  ALADVFSEDS SSSLCQLDIS SNCIKPDGLL EFAKRLERWG RGAFGHLRLF QNWLDQDAVT
   781  AREAIRRLRA TCHVVSDSWD SSQAFADYVS TM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LRRC41 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 53 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 53 nTPM
endometrium: 47 nTPM
ovary: 46 nTPM
fallopian tube: 46 nTPM
cervix: 44 nTPM
urinary bladder: 44 nTPM

Single-cell type

endometrial luminal cells: 986 nCPM
endometrial glandular cells: 516 nCPM
syncytiotrophoblasts: 201 nCPM
cytotrophoblasts: 125 nCPM
endometrial ciliated cells: 120 nCPM
decidual stromal cells: 103 nCPM

Immune cell

myeloid DC: 46 nTPM
classical monocyte: 33 nTPM
NK-cell: 32 nTPM
intermediate monocyte: 31 nTPM
basophil: 30 nTPM
total PBMC: 30 nTPM

Brain region

white matter: 45 nTPM
cerebral cortex: 45 nTPM
medulla oblongata: 45 nTPM
hypothalamus: 43 nTPM
thalamus: 42 nTPM
hippocampal formation: 42 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.19
gnomAD pLI: 1
gnomAD missense Z: 3.08
DepMap mean gene effect: -0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

protein ubiquitination

Molecular functions

identical protein binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Leucine-rich repeat domain superfamily
Leucine-rich repeat-containing 41

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LRRC41 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LRRC41 as an antibody target. Whether an autoantibody or antibody against LRRC41 could matter depends on whether native LRRC41 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LRRC41 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LRRC41 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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