Seroatlas · Human Serome Atlas

COMMD8

COMM domain-containing protein 8

Also known as: COMD8_HUMAN, FLJ20502

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NX08
Gene: COMMD8
Ensembl: ENSG00000169019
Chromosome: 4
Canonical length: 183 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

The protein encoded by this gene binds coiled-coil domain-containing protein 22 (CCDC22), and this complex can regulate the turnover of I-kappa-B and the activation of NF-kappa-B. [provided by RefSeq, Jul 2016]

Canonical amino-acid sequenceUniProt

183 residues, UniProt reviewed canonical sequence.

>Q9NX08|COMMD8
     1  MEPEEGTPLW RLQKLPAELG PQLLHKIIDG ICGRAYPVYQ DYHTVWESEE WMHVLEDIAK
    61  FFKAIVGKNL PDEEIFQQLN QLNSLHQETI MKCVKSRKDE IKQALSREIV AISSAQLQDF
   121  DWQVKLALSS DKIAALRMPL LSLHLDVKEN GEVKPYSIEM SREELQNLIQ SLEAANKVVL
   181  QLK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against COMMD8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 42 nTPM

Expression across tissuesHPA

Tissue

kidney: 42 nTPM
lymph node: 28 nTPM
heart muscle: 25 nTPM
parathyroid gland: 25 nTPM
tonsil: 24 nTPM
esophagus: 23 nTPM

Single-cell type

late primary spermatocytes: 247 nCPM
esophageal suprabasal cells: 154 nCPM
extravillous trophoblasts: 152 nCPM
esophageal apical cells: 148 nCPM
syncytiotrophoblasts: 132 nCPM
oocytes: 120 nCPM

Immune cell

basophil: 115 nTPM
non-classical monocyte: 90 nTPM
intermediate monocyte: 81 nTPM
myeloid DC: 74 nTPM
total PBMC: 71 nTPM
eosinophil: 69 nTPM

Brain region

choroid plexus: 14 nTPM
hypothalamus: 12 nTPM
spinal cord: 8.3 nTPM
midbrain: 8.2 nTPM
white matter: 8.2 nTPM
thalamus: 8.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.77
gnomAD pLI: 0
gnomAD missense Z: 0.04
DepMap mean gene effect: -0.17
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

signal transduction

Molecular functions

NF-kappaB binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

COMM domain
COMM domain-containing protein 4/6/7/8
COMM domain
COMM domain-containing protein 8
COMMD8, helical N-terminal domain
COMMD8, helical N-terminal domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of COMMD8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads COMMD8 as an antibody target. Whether an autoantibody or antibody against COMMD8 could matter depends on whether native COMMD8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

COMMD8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label COMMD8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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