Cullin alpha solenoid domain
PF00888
Definition
This entry represents the N-terminal alpha solenoid domain of the Cullin family. The Cullin family proteins are core components of various cullin-RING E3 ubiquitin-protein ligase complexes. These complexes mediate the ubiquitination and subsequent proteasomal degradation of target proteins, playing crucial roles in cell cycle regulation, signal transduction, and transcription. Cullins act as scaffold proteins, contributing to catalysis by positioning substrates and ubiquitin-conjugating enzymes. The functional specificity of these complexes is determined by variable substrate recognition components, such as F-box proteins in SCF complexes or SOCS box-containing proteins in ECS complexes. Cullins are involved in diverse biological processes, including cell cycle transitions, DNA repair, circadian clock regulation, and stress responses. They also participate in pathways like Wnt signaling, auxin signaling in plants, and hypoxia response through the ubiquitination of hypoxia-inducible factors.
7 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
Loading the interactive Seroatlas explorer...