Seroatlas · Protein domains
Dbl homology (DH) domain superfamily
IPR035899
Definition
The DH domain is composed of 11 α helices that are folded into a flattened, elongated α-helix bundle in which two of the three conserved regions, conserved region 1 (CR1) and conserved region 3 (CR3), are exposed near the centre of one surface. CR1 and CR3, together with a part of alpha-6 and the DH/PH junction site, constitute the Rho GTPase interacting pocket [[cite:PMID:9846881], [cite:PMID:9790532]].
71 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
Download CSV (71 proteins: gene, accession, name)
- ABR
- AKAP13
- ALS2
- ALS2CL
- ARHGEF1
- ARHGEF10
- ARHGEF10L
- ARHGEF11
- ARHGEF12
- ARHGEF15
- ARHGEF16
- ARHGEF17
- ARHGEF18
- ARHGEF19
- ARHGEF2
- ARHGEF25
- ARHGEF26
- ARHGEF28
- ARHGEF3
- ARHGEF33
- ARHGEF37
- ARHGEF38
- ARHGEF39
- ARHGEF4
- ARHGEF40
- ARHGEF5
- ARHGEF6
- ARHGEF7
- ARHGEF9
- BCR
- DNMBP
- ECT2
- ECT2L
- FARP1
- FARP2
- FGD1
- FGD2
- FGD3
- FGD4
- FGD5
- FGD6
- ITSN1
- ITSN2
- KALRN
- MCF2
- MCF2L
- MCF2L2
- NET1
- NGEF
- OBSCN
- PLEKHG1
- PLEKHG2
- PLEKHG3
- PLEKHG4
- PLEKHG4B
- PLEKHG5
- PLEKHG6
- PLEKHG7
- PREX1
- PREX2
- RASGRF1
- RASGRF2
- SOS1
- SOS2
- SPATA13
- TIAM1
- TIAM2
- TRIO
- VAV1
- VAV2
- VAV3
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