Seroatlas · Human Serome Atlas

PLEKHG1

Pleckstrin homology domain-containing family G member 1

Also known as: ARHGEF41, KIAA1209, PKHG1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9ULL1
Gene: PLEKHG1
Ensembl: ENSG00000120278
Chromosome: 6
Canonical length: 1385 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to be involved in regulation of small GTPase mediated signal transduction. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1385 residues, UniProt reviewed canonical sequence.

>Q9ULL1|PLEKHG1
     1  MELSDSDRPV SFGSTSSSAS SRDSHGSFGS RMTLVSNSHM GLFNQDKEVG AIKLELIPAR
    61  PFSSSELQRD NPATGQQNAD EGSERPPRAQ WRVDSNGAPK TIADSATSPK LLYVDRVVQE
   121  ILETERTYVQ DLKSIVEDYL DCIRDQTKLP LGTEERSALF GNIQDIYHFN SELLQDLENC
   181  ENDPVAIAEC FVSKSEEFHI YTQYCTNYPR SVAVLTECMR NKILAKFFRE RQETLKHSLP
   241  LGSYLLKPVQ RILKYHLLLH EIENHLDKDT EGYDVVLDAI DTMQRVAWHI NDMKRKHEHA
   301  VRLQEIQSLL TNWKGPDLTS YGELVLEGTF RIQRAKNERT LFLFDKLLLI TKKRDDTFTY
   361  KAHILCGNLM LVEVIPKEPL SFSVFHYKNP KLQHTVQAKS QQDKRLWVLH LKRLILENHA
   421  AKIPAKAKQA ILEMDAIHHP GFCYSPEGGT KALFGSKEGS APYRLRRKSE PSSRSHKVLK
   481  TSETAQDIQK VSREEGSPQL SSARPSPAQR NSQPSSSTMI SVLRAGGALR NIWTDHQIRQ
   541  ALFPSRRSPQ ENEDDEDDYQ MFVPSFSSSD LNSTRLCEDS TSSRPCSWHM GQMESTETSS
   601  SGHRIVRRAS SAGESNTCPP EIGTSDRTRE LQNSPKTEGQ EEMTPFGSSI ELTIDDIDHV
   661  YDNISYEDLK LMVAKREEAE STPSKSARDS VRPKSTPELA FTKRQAGHSK GSLYAQTDGT
   721  LSGGEASSQS THELQAVEEN IYDTIGLPDP PSLGFKCSSL KRAKRSTFLG LEADFVCCDS
   781  LRPFVSQDSL QLSEDEAPYH QATPDHGYLS LLYDSPSGNL SMPHKPVSDK LSEEVDEIWN
   841  DLENYIKKNE DKARDRLLAA FPVSKDDVPD RLHAESTPEL SRDVGRSVST LSLPESQALL
   901  TPVKSRAGRA SRANCPFEED LISKEGSFMS LNRLSLASEM PLMDNPYDLA NSGLSQTDPE
   961  NPDLGMEATD KTKSRVFMMA RQYSQKIKKA NQLLKVKSLE LEQPPASQHQ KSMHKDLAAI
  1021  LEEKKQGGPA IGARIAEYSQ LYDQIVFRES PLKIQKDGWA SPQESSLLRS VSPSQVHHGS
  1081  GDWLLHSTYS NGELADFCLP PEQDLRSRYP TFEINTKSTP RQLSAACSVP SLQTSDPLPG
  1141  SVQRCSVVVS QPNKENWCQD HLYNSLGRKG ISAKSQPYHR SQSSSSVLIN KSMDSINYPS
  1201  DVGKQQLLSL HRSSRCESHQ DLLPDIADSH QQGTEKLSDL TLQDSQKVVV VNRNLPLNAQ
  1261  IATQNYFSNF KETDGDEDDY VEIKSEEDES ELELSHNRRR KSDSKFVDAD FSDNVCSGNT
  1321  LHSLNSPRTP KKPVNSKLGL SPYLTPYNDS DKLNDYLWRG PSPNQQNIVQ SLREKFQCLS
  1381  SSSFA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLEKHG1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 27 nTPM

Expression across tissuesHPA

Tissue

spleen: 27 nTPM
thymus: 18 nTPM
adipose tissue: 14 nTPM
breast: 14 nTPM
lymph node: 13 nTPM
placenta: 13 nTPM

Single-cell type

vascular endothelial cells: 740 nCPM
lymphatic endothelial cells: 541 nCPM
sertoli cells: 508 nCPM
b-cells: 504 nCPM
pituicytes/fscs: 362 nCPM
podocytes: 302 nCPM

Immune cell

memory B-cell: 23 nTPM
naive B-cell: 22 nTPM
MAIT T-cell: 0.7 nTPM
memory CD8 T-cell: 0.6 nTPM
total PBMC: 0.6 nTPM
naive CD8 T-cell: 0.5 nTPM

Brain region

white matter: 52 nTPM
medulla oblongata: 50 nTPM
thalamus: 48 nTPM
pons: 47 nTPM
spinal cord: 47 nTPM
midbrain: 43 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.41
gnomAD pLI: 0.01
gnomAD missense Z: 0.62
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of small GTPase mediated signal transduction

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PLEKHG1 as an antibody target. Whether an autoantibody or antibody against PLEKHG1 could matter depends on whether native PLEKHG1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PLEKHG1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PLEKHG1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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