PLEKHG7

Protein identityUniProt · HPA

UniProt accession

Q6ZR37

Gene

PLEKHG7

Ensembl

ENSG00000187510

Chromosome

12

Canonical length

691 aa

Protein class

Predicted intracellular proteins

Subcellular location

Centrosome

OverviewNCBI Gene

Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in Rho protein signal transduction. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

691 residues, UniProt reviewed canonical sequence.

>Q6ZR37|PLEKHG7
     1  MEKTESFCPE VPPQDCGASP RPSLRSLPKN QGSLLQFDRQ APGRISTSPT LRRLRTRGCG
    61  TRQDAWQVTT WGSWGAPVGF PCYLSKSLPG SPKDSSHLLS PLRLHSRLTS EPERALNAAD
   121  SLEPQTRPTD KYLPPELQPV NEGSLHQASL RQQEGHFLPS PTLRHPSPQG EELHPSRFYE
   181  HRRSSVVLNL PGLEVFPGDL LVSDGAADYL CHPLLLLNSE SKKPRWPFSK RGVGKDKHKH
   241  ISDLENCLSS VKITSFRGYD FYGLKDKTWD EVLETHHKLP TDQLDLKKQQ EAVWELFTSE
   301  CTYFLDHLLV LKMIFMNTLR YLQTHEYLLD VDLWRLFANL EELTQTSLGF VNSLFGIIKD
   361  YVDASEISSS LDFISVLTKY FRGSLCQSHQ TYCLNYSAAI FYLESLRQRD DFGIYLKWCE
   421  QNEQCRRLHV PELLVAPLQR LTRYPLLLKN IWKRSMDSAE KIMIYSIKEK VEKSIRDLEG
   481  KVKWLDNFQK FRYLQEIIVW PPLWDRDKRF FIPECLKHIF KEHMAENILS PTSRHLLYEG
   541  KLTLAESTRF LDVYLFLFND FLLVTKTKCN KKKLGGSDPG LMCPSLTPEL QAVIKEGGSC
   601  TVLDQPIPLD RLVVKSIEPL HVSVFGLRNA FLIQHENRYR QCIAAFLLQA QTENIKKTWM
   661  AQITTAISCF TKSQETKKIS LFTLPAESSE I

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLEKHG7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Unknown

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.43

Highest tissue expression

2.5 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.54

gnomAD pLI

0

gnomAD missense Z

0.25

DepMap mean gene effect

-0.04

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• Rho protein signal transduction

Molecular functions

• guanyl-nucleotide exchange factor activity

Protein domainsUniProt · Pfam · InterPro

• Dbl homology domain
• Pleckstrin homology domain
• PH-like domain superfamily
• Dbl homology (DH) domain superfamily
• Pleckstrin homology domain-containing family G member 5/7
• RhoGEF domain
• Domain of unknown function (DUF4675)

KeywordsUniProt

• Glycoprotein