Seroatlas · Human Serome Atlas

PLEKHG6

Pleckstrin homology domain-containing family G member 6

Also known as: FLJ10665, MYOGEF, PKHG6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q3KR16
Gene: PLEKHG6
Ensembl: ENSG00000008323
Chromosome: 12
Canonical length: 790 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cell Junctions,Centrosome

OverviewNCBI Gene

Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of small GTPase mediated signal transduction. Located in cell junction and centrosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

790 residues, UniProt reviewed canonical sequence.

>Q3KR16|PLEKHG6
     1  MKAFGPPHEG PLQGLVASRI ETYGGRHRAS AQSTAGRLYP RGYPVLDPSR RRLQQYVPFA
    61  RGSGQARGLS PMRLRDPEPE KRHGGHVGAG LLHSPKLKEL TKAHELEVRL HTFSMFGMPR
   121  LPPEDRRHWE IGEGGDSGLT IEKSWRELVP GHKEMSQELC HQQEALWELL TTELIYVRKL
   181  KIMTDLLAAG LLNLQRVGLL MEVSAETLFG NVPSLIRTHR SFWDEVLGPT LEETRASGQP
   241  LDPIGLQSGF LTFGQRFHPY VQYCLRVKQT MAYAREQQET NPLFHAFVQW CEKHKRSGRQ
   301  MLCDLLIKPH QRITKYPLLL HAVLKRSPEA RAQEALNAMI EAVESFLRHI NGQVRQGEEQ
   361  ESLAAAAQRI GPYEVLEPPS DEVEKNLRPF STLDLTSPML GVASEHTRQL LLEGPVRVKE
   421  GREGKLDVYL FLFSDVLLVT KPQRKADKAK VIRPPLMLEK LVCQPLRDPN SFLLIHLTEF
   481  QCVSSALLVH CPSPTDRAQW LEKTQQAQAA LQKLKAEEYV QQKRELLTLY RDQDRESPST
   541  RPSTPSLEGS QSSAEGRTPE FSTIIPHLVV TEDTDEDAPL VPDDTSDSGY GTLIPGTPTG
   601  SRSPLSRLRQ RALRRDPRLT FSTLELRDIP LRPHPPDPQA PQRRSAPELP EGILKGGSLP
   661  QEDPPTWSEE EDGASERGNV VVETLHRARL RGQLPSSPTH ADSAGESPWE SSGEEEEEGP
   721  LFLKAGHTSL RPMRAEDMLR EIREELASQR IEGAEEPRDS RPRKLTRAQL QRMRGPHIIQ
   781  LDTPLSASEV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLEKHG6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 38 nTPM

Expression across tissuesHPA

Tissue

small intestine: 38 nTPM
duodenum: 32 nTPM
colon: 26 nTPM
esophagus: 25 nTPM
rectum: 15 nTPM
urinary bladder: 14 nTPM

Single-cell type

enterocytes: 170 nCPM
colonocytes: 152 nCPM
epicardial cells: 130 nCPM
esophageal apical cells: 125 nCPM
extravillous trophoblasts: 122 nCPM
tuft cells: 92 nCPM

Immune cell

plasmacytoid DC: 1.1 nTPM
neutrophil: 0.7 nTPM
basophil: 0.2 nTPM
eosinophil: 0.1 nTPM
naive CD8 T-cell: 0.1 nTPM
classical monocyte: 0 nTPM

Brain region

choroid plexus: 7.1 nTPM
cerebral cortex: 6.5 nTPM
midbrain: 6.2 nTPM
white matter: 6.2 nTPM
medulla oblongata: 6.1 nTPM
cerebellum: 6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1
gnomAD pLI: 0
gnomAD missense Z: 0
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of small GTPase mediated signal transduction

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Dbl homology domain
Pleckstrin homology domain
PH-like domain superfamily
Dbl homology (DH) domain superfamily
RhoGEF domain
Pleckstrin homology domain-containing family G member 6

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PLEKHG6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PLEKHG6 as an antibody target. Whether an autoantibody or antibody against PLEKHG6 could matter depends on whether native PLEKHG6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PLEKHG6 is annotated at the cell surface, where native PLEKHG6 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PLEKHG6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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