Seroatlas · Human Serome Atlas

ARHGEF7

Rho guanine nucleotide exchange factor 7

Also known as: ARHG7_HUMAN, BETA-PIX, COOL1, DKFZp686C12170, DKFZp761K1021, KIAA0142, Nbla10314, P50, P50BP, P85, P85COOL1, P85SPR, PAK3, PIXB

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q14155
Gene
ARHGEF7
Ensembl
ENSG00000102606
Chromosome
13
Canonical length
803 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a protein that belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It forms a complex with the small GTP binding protein Rac1 and recruits Rac1 to membrane ruffles and to focal adhesions. Multiple alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Mar 2016]

Canonical amino-acid sequenceUniProt

803 residues, UniProt reviewed canonical sequence.

>Q14155|ARHGEF7
     1  MNSAEQTVTW LITLGVLESP KKTISDPEGF LQASLKDGVV LCRLLERLLP GTIEKVYPEP
    61  RSESECLSNI REFLRGCGAS LRLELLFPPS QPPQHLVTTI LLSASTFDAN DLYQGQNFNK
   121  VLSSLVTLNK VTADIGLGSD SVCARPSSHR IKSFDSLGSQ SLHTRTSKLF QGQYRSLDMT
   181  DNSNNQLVVR AKFNFQQTNE DELSFSKGDV IHVTRVEEGG WWEGTLNGRT GWFPSNYVRE
   241  VKASEKPVSP KSGTLKSPPK GFDTTAINKS YYNVVLQNIL ETENEYSKEL QTVLSTYLRP
   301  LQTSEKLSSA NISYLMGNLE EICSFQQMLV QSLEECTKLP EAQQRVGGCF LNLMPQMKTL
   361  YLTYCANHPS AVNVLTEHSE ELGEFMETKG ASSPGILVLT TGLSKPFMRL DKYPTLLKEL
   421  ERHMEDYHTD RQDIQKSMAA FKNLSAQCQE VRKRKELELQ ILTEAIRNWE GDDIKTLGNV
   481  TYMSQVLIQC AGSEEKNERY LLLFPNVLLM LSASPRMSGF IYQGKLPTTG MTITKLEDSE
   541  NHRNAFEISG SMIERILVSC NNQQDLQEWV EHLQKQTKVT SVGNPTIKPH SVPSHTLPSH
   601  PVTPSSKHAD SKPAPLTPAY HTLPHPSHHG TPHTTINWGP LEPPKTPKPW SLSCLRPAPP
   661  LRPSAALCYK EDLSKSPKTM KKLLPKRKPE RKPSDEEFAS RKSTAALEED AQILKVIEAY
   721  CTSAKTRQTL NSTWQGTDLM HNHVLADDDQ PSLDSLGRRS SLSRLEPSDL SEDSDYDSIW
   781  TAHSYRMGST SRKSCCSYIS HQN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARHGEF7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.45
Highest tissue expression
71 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 71 nTPM
  • thymus: 61 nTPM
  • blood vessel: 58 nTPM
  • adipose tissue: 54 nTPM
  • cerebral cortex: 53 nTPM
  • breast: 50 nTPM

Single-cell type

  • vascular smooth muscle cells: 423 nCPM
  • thymocytes: 359 nCPM
  • oligodendrocytes: 338 nCPM
  • innate lymphoid cells: 312 nCPM
  • pericytes: 292 nCPM
  • corticotrophs: 275 nCPM

Immune cell

  • basophil: 30 nTPM
  • NK-cell: 12 nTPM
  • MAIT T-cell: 10 nTPM
  • memory B-cell: 9.9 nTPM
  • naive B-cell: 9.2 nTPM
  • T-reg: 8.4 nTPM

Brain region

  • white matter: 175 nTPM
  • cerebral cortex: 160 nTPM
  • cerebellum: 155 nTPM
  • hippocampal formation: 146 nTPM
  • basal ganglia: 141 nTPM
  • thalamus: 129 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.19
gnomAD pLI
1
gnomAD missense Z
2.57
DepMap mean gene effect
-0.25
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ARHGEF7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARHGEF7 as an antibody target. Whether an autoantibody or antibody against ARHGEF7 could matter depends on whether native ARHGEF7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARHGEF7 is annotated at the cell surface, where native ARHGEF7 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ARHGEF7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ARHGEF7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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