Seroatlas · Human Serome Atlas

VAV2

Guanine nucleotide exchange factor VAV2

Also known as: VAV2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P52735
Gene
VAV2
Ensembl
ENSG00000160293
Chromosome
9
Canonical length
878 aa
Protein class
Plasma proteins, Predicted intracellular proteins, Transporters
Subcellular location
Vesicles

OverviewNCBI Gene

VAV2 is the second member of the VAV guanine nucleotide exchange factor family of oncogenes. Unlike VAV1, which is expressed exclusively in hematopoietic cells, VAV2 transcripts were found in most tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

Canonical amino-acid sequenceUniProt

878 residues, UniProt reviewed canonical sequence.

>P52735|VAV2
     1  MEQWRQCGRW LIDCKVLPPN HRVVWPSAVV FDLAQALRDG VLLCQLLHNL SPGSIDLKDI
    61  NFRPQMSQFL CLKNIRTFLK VCHDKFGLRN SELFDPFDLF DVRDFGKVIS AVSRLSLHSI
   121  AQNKGIRPFP SEETTENDDD VYRSLEELAD EHDLGEDIYD CVPCEDGGDD IYEDIIKVEV
   181  QQPMIRYMQK MGMTEDDKRN CCLLEIQETE AKYYRTLEDI EKNYMSPLRL VLSPADMAAV
   241  FINLEDLIKV HHSFLRAIDV SVMVGGSTLA KVFLDFKERL LIYGEYCSHM EHAQNTLNQL
   301  LASREDFRQK VEECTLKVQD GKFKLQDLLV VPMQRVLKYH LLLKELLSHS AERPERQQLK
   361  EALEAMQDLA MYINEVKRDK ETLRKISEFQ SSIENLQVKL EEFGRPKIDG ELKVRSIVNH
   421  TKQDRYLFLF DKVVIVCKRK GYSYELKEII ELLFHKMTDD PMNNKDVKKS HGKMWSYGFY
   481  LIHLQGKQGF QFFCKTEDMK RKWMEQFEMA MSNIKPDKAN ANHHSFQMYT FDKTTNCKAC
   541  KMFLRGTFYQ GYMCTKCGVG AHKECLEVIP PCKFTSPADL DASGAGPGPK MVAMQNYHGN
   601  PAPPGKPVLT FQTGDVLELL RGDPESPWWE GRLVQTRKSG YFPSSSVKPC PVDGRPPISR
   661  PPSREIDYTA YPWFAGNMER QQTDNLLKSH ASGTYLIRER PAEAERFAIS IKFNDEVKHI
   721  KVVEKDNWIH ITEAKKFDSL LELVEYYQCH SLKESFKQLD TTLKYPYKSR ERSASRASSR
   781  SPASCASYNF SFLSPQGLSF ASQGPSAPFW SVFTPRVIGT AVARYNFAAR DMRELSLREG
   841  DVVRIYSRIG GDQGWWKGET NGRIGWFPST YVEEEGIQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against VAV2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.3
Highest tissue expression
44 nTPM

Expression across tissuesHPA

Tissue

  • liver: 44 nTPM
  • pancreas: 37 nTPM
  • adrenal gland: 26 nTPM
  • kidney: 22 nTPM
  • small intestine: 21 nTPM
  • duodenum: 20 nTPM

Single-cell type

  • renal collecting duct principal cells: 219 nCPM
  • renal connecting tubule cells: 197 nCPM
  • podocytes: 117 nCPM
  • pancreatic acinar cells: 116 nCPM
  • enterocytes: 113 nCPM
  • renal collecting duct intercalated cells: 112 nCPM

Immune cell

  • memory B-cell: 3.3 nTPM
  • naive B-cell: 2.1 nTPM
  • intermediate monocyte: 2 nTPM
  • non-classical monocyte: 1.4 nTPM
  • myeloid DC: 1.1 nTPM
  • classical monocyte: 0.8 nTPM

Brain region

  • midbrain: 30 nTPM
  • pons: 24 nTPM
  • medulla oblongata: 20 nTPM
  • cerebral cortex: 20 nTPM
  • choroid plexus: 19 nTPM
  • hypothalamus: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.52
gnomAD pLI
0
gnomAD missense Z
1.49
DepMap mean gene effect
-0.07
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of VAV2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads VAV2 as an antibody target. Whether an autoantibody or antibody against VAV2 could matter depends on whether native VAV2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

VAV2 is annotated at the cell surface, where native VAV2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label VAV2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/VAV2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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