Seroatlas · Human Serome Atlas

ARHGEF16

Rho guanine nucleotide exchange factor 16

Also known as: ARHGG_HUMAN, GEF16, NBR

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5VV41
Gene: ARHGEF16
Ensembl: ENSG00000130762
Chromosome: 1
Canonical length: 709 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Although the specific function of this protein is not known yet, it is thought to be involved in protein-protein and protein-lipid interactions. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

709 residues, UniProt reviewed canonical sequence.

>Q5VV41|ARHGEF16
     1  MAQRHSDSSL EEKLLGHRFH SELRLDAGGN PASGLPMVRG SPRVRDDAAF QPQVPAPPQP
    61  RPPGHEEPWP IVLSTESPAA LKLGTQQLIP KSLAVASKAK TPARHQSFGA AVLSREAARR
   121  DPKLLPAPSF SLDDMDVDKD PGGMLRRNLR NQSYRAAMKG LGKPGGQGDA IQLSPKLQAL
   181  AEEPSQPHTR SPAKNKKTLG RKRGHKGSFK DDPQLYQEIQ ERGLNTSQES DDDILDESSS
   241  PEGTQKVDAT IVVKSYRPAQ VTWSQLPEVV ELGILDQLST EERKRQEAMF EILTSEFSYQ
   301  HSLSILVEEF LQSKELRATV TQMEHHHLFS NILDVLGASQ RFFEDLEQRH KAQVLVEDIS
   361  DILEEHAEKH FHPYIAYCSN EVYQQRTLQK LISSNAAFRE ALREIERRPA CGGLPMLSFL
   421  ILPMQRVTRL PLLMDTLCLK TQGHSERYKA ASRALKAISK LVRQCNEGAH RMERMEQMYT
   481  LHTQLDFSKV KSLPLISASR WLLKRGELFL VEETGLFRKI ASRPTCYLFL FNDVLVVTKK
   541  KSEESYMVQD YAQMNHIQVE KIEPSELPLP GGGNRSSSVP HPFQVTLLRN SEGRQEQLLL
   601  SSDSASDRAR WIVALTHSER QWQGLSSKGD LPQVEITKAF FAKQADEVTL QQADVVLVLQ
   661  QEDGWLYGER LRDGETGWFP EDFARFITSR VAVEGNVRRM ERLRVETDV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARHGEF16 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 41 nTPM

Expression across tissuesHPA

Tissue

duodenum: 41 nTPM
small intestine: 32 nTPM
stomach: 27 nTPM
colon: 20 nTPM
kidney: 19 nTPM
esophagus: 18 nTPM

Single-cell type

tuft cells: 104 nCPM
extravillous trophoblasts: 92 nCPM
colonocytes: 79 nCPM
enterocytes: 76 nCPM
goblet cells: 69 nCPM
foveolar cells: 63 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

pons: 11 nTPM
choroid plexus: 10 nTPM
medulla oblongata: 8.2 nTPM
hypothalamus: 7.6 nTPM
thalamus: 6 nTPM
white matter: 6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.02
gnomAD pLI: 0
gnomAD missense Z: 0.46
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

cytosol

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ARHGEF16 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARHGEF16 as an antibody target. Whether an autoantibody or antibody against ARHGEF16 could matter depends on whether native ARHGEF16 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARHGEF16 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ARHGEF16 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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