Seroatlas · Human Serome Atlas

PLEKHG4B

Pleckstrin homology domain-containing family G member 4B

Also known as: KIAA1909, PKH4B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96PX9
Gene: PLEKHG4B
Ensembl: ENSG00000153404
Chromosome: 5
Canonical length: 1627 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

This gene encodes a large protein that contains a pleckstrin homology domain and may function as a guanine nucleotide exchange factor. [provided by RefSeq, May 2017]

Canonical amino-acid sequenceUniProt

1627 residues, UniProt reviewed canonical sequence.

>Q96PX9|PLEKHG4B
     1  MGFSTADGGG GPGARDLESL DACIQRTLSA LYPPFEATAA TVLWQLFSVA ERCHGGDGLH
    61  CLTSFLLPAK RALQHLQQEA CARYRGLVFL HPGWPLCAHE KVVVQLASLH GVRLQPGDFY
   121  LQVTSAGKQS ARLVLKCLSR LGRGTEEVTV PEAMYGCVFT GAFLEWVNRE RRHVPLQTCL
   181  LTSGLAVHRA PWSDVTDPVF VPSPGAILQS YSSCTGPERL PSSPSEAPVP TQATAGPHFQ
   241  GSASCPDTLT SPCRRGHTGS DQLRHLPYPE RAELGSPRTL SGSSDRDFEK VSPSEQGPRM
   301  PPENCGGSGE RPDPMDQEDR PKALTFHTDL GIPSSRRRPP GDPTCVQPRR WFRESYMEAL
   361  RNPMPLGSSE EALGDLACSS LTGASRDLGT GAVASGTQEE TSGPRGDPQQ TPSLEKERHT
   421  PSRTGPGAAG RTLPRRSRSW ERAPRSSRGA QAAACHTSHH SAGSRPGGHL GGQAVGTPNC
   481  VPVEGPGCTK EEDVLASSAC VSTDGGSLHC HNPSGPSDVP ARQPHPEQEG WPPGTGDFPS
   541  QVPKQVLDVS QELLQSGVVT LPGTRDRHGR AVVQVRTRSL LWTREHSSCA ELTRLLLYFH
   601  SIPRKEVRDL GLVVLVDARR SPAAPAVSQA LSGLQNNTSP IIHSILLLVD KESAFRPDKD
   661  AIIQCEVVSS LKAVHKFVDS CQLTADLDGS FPYSHGDWIC FRQRLEHFAA NCEEAIIFLQ
   721  NSFCSLNTHR TPRTAQEVAE LIDQHETMMK LVLEDPLLVS LRLEGGTVLA RLRREELGTE
   781  DSRDTLEAAT SLYDRVDEEV HRLVLTSNNR LQQLEHLREL ASLLEGNDQQ SCQKGLQLAK
   841  ENPQRTEEMV QDFRRGLSAV VSQAECREGE LARWTRSSEL CETVSSWMGP LDPEACPSSP
   901  VAECLRSCHQ EATSVAAEAF PGAGVAVLKP HALGKPWASQ QDLWLQYPQT RLRLEEALSE
   961  AAPDPSLPPL AQSPPKHERA QEAMRRHQKP PSFPSTDSGG GAWEPAQPLS GLPGRALLCG
  1021  QDGETLRPGL CALWDPLSLL RGLPGAGATT AHLEDSSACS SEPTQTLASR PRKHPQKKMI
  1081  KKTQSFEIPQ PDSGPRDSCQ PDHTSVFSKG LEVTSTVATE KKLPLWQHAR SPPVTQSRSL
  1141  SSPSGLHPAE EDGRQQVGSS RLRHIMAEMI ATEREYIRCL GYVIDNYFPE MERMDLPQGL
  1201  RGKHHVIFGN LEKLHDFHQQ HFLRELERCQ HCPLAVGRSF LRHEEQFGMY VIYSKNKPQS
  1261  DALLSSHGNA FFKDKQRELG DKMDLASYLL RPVQRVAKYA LLLQDLLKEA SCGLAQGQEL
  1321  GELRAAEVVV CFQLRHGNDL LAMDAIRGCD VNLKEQGQLR CRDEFIVCCG RKKYLRHVFL
  1381  FEDLILFSKT QKVEGSHDVY LYKQSFKTAE IGMTENVGDS GLRFEIWFRR RRKSQDTYIL
  1441  QASSAEVKSA WTDVIGRILW RQALKSRELR IQEMASMGIG NQPFMDVKPR DRTPDCAVIS
  1501  DRAPKCAVMS DRVPDSIVKG TESQMRGSTA VSSSDHAAPF KRPHSTISDS STSSSSSQSS
  1561  SILGSLGLLV SSSPAHPGLW SPAHSPWSSD IRACVEEDEP EPELETGTQA AVCEGAPAVL
  1621  LSRTRQA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLEKHG4B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 7.9 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 7.9 nTPM
pituitary gland: 3.4 nTPM
thyroid gland: 3 nTPM
testis: 2.8 nTPM
salivary gland: 2.6 nTPM
kidney: 2.3 nTPM

Single-cell type

choroid plexus epithelial cells: 235 nCPM
ependymal cells: 122 nCPM
gonadotrophs: 108 nCPM
pituitary stem cells: 68 nCPM
renal collecting duct principal cells: 58 nCPM
somatotrophs: 43 nCPM

Immune cell

plasmacytoid DC: 1.9 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

choroid plexus: 21 nTPM
thalamus: 5.9 nTPM
amygdala: 4.2 nTPM
white matter: 3.3 nTPM
midbrain: 2.8 nTPM
hypothalamus: 2.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.22
gnomAD pLI: 0
gnomAD missense Z: -0.27
DepMap mean gene effect: 0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

guanyl-nucleotide exchange factor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PLEKHG4B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PLEKHG4B as an antibody target. Whether an autoantibody or antibody against PLEKHG4B could matter depends on whether native PLEKHG4B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PLEKHG4B is annotated at the cell surface, where native PLEKHG4B is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PLEKHG4B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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