VAV3

Protein identityUniProt · HPA

UniProt accession

Q9UKW4

Gene

VAV3

Ensembl

ENSG00000134215

Chromosome

1

Canonical length

847 aa

Protein class

Predicted intracellular proteins

OverviewNCBI Gene

This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free states of these GTPases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

847 residues, UniProt reviewed canonical sequence.

>Q9UKW4|VAV3
     1  MEPWKQCAQW LIHCKVLPTN HRVTWDSAQV FDLAQTLRDG VLLCQLLNNL RAHSINLKEI
    61  NLRPQMSQFL CLKNIRTFLT ACCETFGMRK SELFEAFDLF DVRDFGKVIE TLSRLSRTPI
   121  ALATGIRPFP TEESINDEDI YKGLPDLIDE TLVEDEEDLY DCVYGEDEGG EVYEDLMKAE
   181  EAHQPKCPEN DIRSCCLAEI KQTEEKYTET LESIEKYFMA PLKRFLTAAE FDSVFINIPE
   241  LVKLHRNLMQ EIHDSIVNKN DQNLYQVFIN YKERLVIYGQ YCSGVESAIS SLDYISKTKE
   301  DVKLKLEECS KRANNGKFTL RDLLVVPMQR VLKYHLLLQE LVKHTTDPTE KANLKLALDA
   361  MKDLAQYVNE VKRDNETLRE IKQFQLSIEN LNQPVLLFGR PQGDGEIRIT TLDKHTKQER
   421  HIFLFDLAVI VCKRKGDNYE MKEIIDLQQY KIANNPTTDK ENKKWSYGFY LIHTQGQNGL
   481  EFYCKTKDLK KKWLEQFEMA LSNIRPDYAD SNFHDFKMHT FTRVTSCKVC QMLLRGTFYQ
   541  GYLCFKCGAR AHKECLGRVD NCGRVNSGEQ GTLKLPEKRT NGLRRTPKQV DPGLPKMQVI
   601  RNYSGTPPPA LHEGPPLQLQ AGDTVELLKG DAHSLFWQGR NLASGEVGFF PSDAVKPCPC
   661  VPKPVDYSCQ PWYAGAMERL QAETELINRV NSTYLVRHRT KESGEYAISI KYNNEAKHIK
   721  ILTRDGFFHI AENRKFKSLM ELVEYYKHHS LKEGFRTLDT TLQFPYKEPE HSAGQRGNRA
   781  GNSLLSPKVL GIAIARYDFC ARDMRELSLL KGDVVKIYTK MSANGWWRGE VNGRVGWFPS
   841  TYVEEDE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against VAV3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.3

Highest tissue expression

78 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.72

gnomAD pLI

0

gnomAD missense Z

1.13

DepMap mean gene effect

-0.1

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• angiogenesis
• B cell receptor signaling pathway
• cell migration
• DNA damage response
• Fc-epsilon receptor signaling pathway
• Fc-gamma receptor signaling pathway involved in phagocytosis
• immune response-regulating cell surface receptor signaling pathway
• integrin-mediated signaling pathway
• lamellipodium assembly
• neutrophil chemotaxis
• platelet activation
• positive regulation of B cell proliferation
• positive regulation of cell adhesion
• positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
• regulation of cell size
• regulation of small GTPase mediated signal transduction
• response to xenobiotic stimulus
• small GTPase-mediated signal transduction
• vesicle fusion

Molecular functions

• epidermal growth factor receptor binding
• GTPase activator activity
• guanyl-nucleotide exchange factor activity
• zinc ion binding

Cellular components

• cytoplasm
• cytosol
• immunological synapse
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Dbl homology domain
• SH2 domain
• Guanine-nucleotide dissociation stimulator, CDC24, conserved site
• SH3 domain
• Calponin homology domain
• Pleckstrin homology domain
• Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
• Smooth muscle protein/calponin
• PH-like domain superfamily
• CASAMP, second calponin-homology domain
• Dbl homology (DH) domain superfamily
• SH3-like domain superfamily
• SH2 domain superfamily
• CH domain superfamily
• Vav, PH domain
• SOS1/NGEF-like, PH domain
• SH2 domain
• Phorbol esters/diacylglycerol binding domain (C1 domain)
• RhoGEF domain
• Variant SH3 domain
• CAMSAP CH domain
• SOS1/NGEF-like PH domain
• VAV3 protein, second SH3 domain
• VAV3, SH2 domain
• VAV3 protein, first SH3 domain

KeywordsUniProt

• Alternative promoter usage
• Angiogenesis
• Guanine-nucleotide releasing factor
• Metal-binding
• Phosphoprotein
• Repeat
• SH2 domain
• SH3 domain
• Zinc
• Zinc-finger

InteractionsUniProt · HPA

Protein binding partners of VAV3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• ROS1
• SH2B2
• BLNK
• GRB2