Seroatlas · Human Serome Atlas

FGD2

FYVE, RhoGEF and PH domain-containing protein 2

Also known as: FGD2_HUMAN, ZFYVE4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q7Z6J4
Gene
FGD2
Ensembl
ENSG00000146192
Chromosome
6
Canonical length
655 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene belongs to a family of guanine nucleotide exchange factors (GEFs) which control cytoskeleton-dependent membrane rearrangements by activating the cell division cycle 42 (CDC42) protein. This gene is expressed in B lymphocytes, macrophages, and dendritic cells. The encoded protein may play a role in leukocyte signaling and vesicle trafficking in antigen-presenting cells in the immune system. [provided by RefSeq, Oct 2016]

Canonical amino-acid sequenceUniProt

655 residues, UniProt reviewed canonical sequence.

>Q7Z6J4|FGD2
     1  MKGASEEKLA SVSNLVTVFE NSRTPEAAPR GQRLEDVHHR PECRPPESPG PREKTNVGEA
    61  VGSEPRTVSR RYLNSLKNKL SSEAWRKSCQ PVTLSGSGTQ EPEKKIVQEL LETEQAYVAR
   121  LHLLDQVFFQ ELLKTARSSK AFPEDVVRVI FSNISSIYQF HSQFFLPELQ RRLDDWTANP
   181  RIGDVIQKLA PFLKMYSEYV KNFERAAELL ATWTDKSPLF QEVLTRIQSS EASGSLTLQH
   241  HMLEPVQRIP RYELLLKEYI QKLPAQAPDQ ADAQKALDMI FSAAQHSNAA ITEMERLQDL
   301  WEVYQRLGLE DDIVDPSNTL LREGPVLKIS FRRNDPMERY LFLFNNMLLY CVPRVIQVGA
   361  QFQVRTRIDV AGMKVRELMD AEFPHSFLVS GKQRTLELQA RSQEEMISWM QAFQAAIDQI
   421  EKRNETFKAA AQGPEGDIQE QELQSEELGL RAPQWVRDKM VTMCMRCQEP FNALTRRRHH
   481  CRACGYVVCA RCSDYRAELK YDDNRPNRVC LHCYAFLTGN VLPEAKEDKR RGILEKGSSA
   541  TPDQSLMCSF LQLIGDKWGK SGPRGWCVIP RDDPLVLYVY AAPQDMRAHT SIPLLGYQVT
   601  VGPQGDPRVF QLQQSGQLYT FKAETEELKG RWVKAMERAA SGWSPSWPND GDLSD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FGD2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
40 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 40 nTPM
  • lymph node: 21 nTPM
  • appendix: 14 nTPM
  • small intestine: 11 nTPM
  • tonsil: 9.2 nTPM
  • lung: 7.9 nTPM

Single-cell type

  • microglia: 285 nCPM
  • kupffer cells: 221 nCPM
  • macrophages: 165 nCPM
  • cdc: 154 nCPM
  • b-cells: 135 nCPM
  • monocytes: 129 nCPM

Immune cell

  • non-classical monocyte: 72 nTPM
  • intermediate monocyte: 66 nTPM
  • myeloid DC: 36 nTPM
  • plasmacytoid DC: 28 nTPM
  • memory B-cell: 24 nTPM
  • classical monocyte: 23 nTPM

Brain region

  • medulla oblongata: 6.4 nTPM
  • spinal cord: 4.7 nTPM
  • choroid plexus: 4.6 nTPM
  • thalamus: 4.3 nTPM
  • white matter: 4.2 nTPM
  • pons: 3.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.81
gnomAD pLI
0
gnomAD missense Z
0.7
DepMap mean gene effect
-0.11
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FGD2 as an antibody target. Whether an autoantibody or antibody against FGD2 could matter depends on whether native FGD2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FGD2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FGD2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FGD2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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