Seroatlas · Human Serome Atlas

ARHGEF26

Rho guanine nucleotide exchange factor 26

Also known as: ARHGQ_HUMAN, DKFZP434D146, SGEF

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96DR7
Gene
ARHGEF26
Ensembl
ENSG00000114790
Chromosome
3
Canonical length
871 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Plasma membrane,Cytosol

OverviewNCBI Gene

This gene encodes a member of the Rho-guanine nucleotide exchange factor (Rho-GEF) family. These proteins regulate Rho GTPases by catalyzing the exchange of GDP for GTP. The encoded protein specifically activates RhoG and plays a role in the promotion of macropinocytosis. Underexpression of the encoded protein may be a predictive marker of chemoresistant disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]

Canonical amino-acid sequenceUniProt

871 residues, UniProt reviewed canonical sequence.

>Q96DR7|ARHGEF26
     1  MDGESEVDFS SNSITPLWRR RSIPQPHQVL GRSKPRPQSY QSPNGLLITD FPVEDGGTLL
    61  AAQIPAQVPT ASDSRTVHRS PLLLGAQRRA VANGGTASPE YRAASPRLRR PKSPKLPKAV
   121  PGGSPKSPAN GAVTLPAPPP PPVLRPPRTP NAPAPCTPEE DLTGLTASPV PSPTANGLAA
   181  NNDSPGSGSQ SGRKAKDPER GLFPGPQKSS SEQKLPLQRL PSQENELLEN PSVVLSTNSP
   241  AALKVGKQQI IPKSLASEIK ISKSNNQNVE PHKRLLKVRS MVEGLGGPLG HAGEESEVDN
   301  DVDSPGSLRR GLRSTSYRRA VVSGFDFDSP TSSKKKNRMS QPVLKVVMED KEKFSSLGRI
   361  KKKMLKGQGT FDGEENAVLY QNYKEKALDI DSDEESEPKE QKSDEKIVIH HKPLRSTWSQ
   421  LSAVKRKGLS QTVSQEERKR QEAIFEVISS EHSYLLSLEI LIRMFKNSKE LSDTMTKTER
   481  HHLFSNITDV CEASKKFFIE LEARHQNNIF IDDISDIVEK HTASTFDPYV KYCTNEVYQQ
   541  RTLQKLLATN PSFKEVLSRI ESHEDCRNLP MISFLILPMQ RVTRLPLLMD TICQKTPKDS
   601  PKYEVCKRAL KEVSKLVRLC NEGARKMERT EMMYTINSQL EFKIKPFPLV SSSRWLVKRG
   661  ELTAYVEDTV LFSRRTSKQQ VYFFLFNDVL IITKKKSEES YNVNDYSLRD QLLVESCDNE
   721  ELNSSPGKNS STMLYSRQSS ASHLFTLTVL SNHANEKVEM LLGAETQSER ARWITALGHS
   781  SGKPPADRTS LTQVEIVRSF TAKQPDELSL QVADVVLIYQ RVSDGWYEGE RLRDGERGWF
   841  PMECAKEITC QATIDKNVER MGRLLGLETN V

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARHGEF26 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.47
Highest tissue expression
17 nTPM

Expression across tissuesHPA

Tissue

  • colon: 17 nTPM
  • lung: 15 nTPM
  • liver: 15 nTPM
  • blood vessel: 11 nTPM
  • cerebral cortex: 9.6 nTPM
  • parathyroid gland: 9.3 nTPM

Single-cell type

  • podocytes: 836 nCPM
  • bergmann glia: 390 nCPM
  • astrocytes: 342 nCPM
  • choroid plexus epithelial cells: 307 nCPM
  • ependymal cells: 261 nCPM
  • breast lactating cells: 68 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • choroid plexus: 22 nTPM
  • midbrain: 21 nTPM
  • thalamus: 19 nTPM
  • medulla oblongata: 18 nTPM
  • hypothalamus: 18 nTPM
  • amygdala: 18 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ARHGEF26.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 160 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.99
gnomAD pLI
0
gnomAD missense Z
-1.02
DepMap mean gene effect
0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ARHGEF26 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARHGEF26 as an antibody target. Whether an autoantibody or antibody against ARHGEF26 could matter depends on whether native ARHGEF26 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARHGEF26 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ARHGEF26 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ARHGEF26. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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