Seroatlas · Human Serome Atlas

MCF2L2

Probable guanine nucleotide exchange factor MCF2L2

Also known as: ARHGEF22, KIAA0861, MF2L2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86YR7
Gene: MCF2L2
Ensembl: ENSG00000053524
Chromosome: 3
Canonical length: 1114 aa
Protein class: Disease related genes, Predicted intracellular proteins
Subcellular location: Centriolar satellite,Cytosol

OverviewNCBI Gene

Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be located in cytosol. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1114 residues, UniProt reviewed canonical sequence.

>Q86YR7|MCF2L2
     1  MLSCLKEEMP PQELTRRLAT VITHVDEIMQ QEVRPLMAVE IIEQLHRQFA ILSGGRGEDG
    61  APIITFPEFS GFKHIPDEDF LNVMTYLTSI PSVEAASIGF IVVIDRRRDK WSSVKASLTR
   121  IAVAFPGNLQ LIFILRPSRF IQRTFTDIGI KYYRNEFKTK VPIIMVNSVS DLHGYIDKSQ
   181  LTRELGGTLE YRHGQWVNHR TAIENFALTL KTTAQMLQTF GSCLATAELP RSMLSTEDLL
   241  MSHTRQRDKL QDELKLLGKQ GTTLLSCIQE PATKCPNSKL NLNQLENVTT MERLLVQLDE
   301  TEKAFSHFWS EHHLKLNQCL QLQHFEHDFC KAKLALDNLL EEQAEFTGIG DSVMHVEQIL
   361  KEHKKLEEKS QEPLEKAQLL ALVGDQLIQS HHYAADAIRP RCVELRHLCD DFINGNKKKW
   421  DILGKSLEFH RQLDKVSQWC EAGIYLLASQ AVDKCQSREG VDIALNDIAT FLGTVKEYPL
   481  LSPKEFYNEF ELLLTLDAKA KAQKVLQRLD DVQEIFHKRQ VSLMKLAAKQ TRPVQPVAPH
   541  PESSPKWVSS KTSQPSTSVP LARPLRTSEE PYTETELNSR GKEDDETKFE VKSEEIFESH
   601  HERGNPELEQ QARLGDLSPR RRIIRDLLET EEIYIKEIKS IIDGYITPMD FIWLKHLIPD
   661  VLQNNKDFLF GNIRELYEFH NRTFLKELEK CAENPELLAH CFLKRKEDLQ IYFKYHKNLP
   721  RARAIWQECQ DCAYFGVCQR QLDHNLPLFK YLKGPSQRLI KYQMLLKGLL DFESPEDMEI
   781  DPGELGGSAK DGPKRTKDSA FSTELQQALA VIEDLIKSCE LAVDLAAVTE CPDDIGKLGK
   841  LLLHGPFSVW TIHKDRYKMK DLIRFKPSQR QIYLFERGIV FCKIRMEPGD QGLSPHYSFK
   901  KTMKLMTLSI RQLGRGSHRK FEIASRNGLE KYILQAASKE IRDCWFSEIS KLLMEQQNNI
   961  KDQGNPQFEM STSKGSGAGS GPWIKNMERA TTSKEDPASS TGGIKGCSSR EFSSMDTFED
  1021  CEGAEDMEKE SSALSLAGLF QSDDSHETCS SKSAFLERGE SSQGEKEERD EEETATRSTE
  1081  EERAGASTGR LAPAGATAGF QARALRPRTS AQES

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MCF2L2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 33 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 33 nTPM
retina: 26 nTPM
basal ganglia: 16 nTPM
amygdala: 16 nTPM
hippocampal formation: 13 nTPM
hypothalamus: 8.6 nTPM

Single-cell type

cone photoreceptor cells: 1,045 nCPM
adrenal cortex cells: 977 nCPM
rod photoreceptor cells: 733 nCPM
esophageal apical cells: 732 nCPM
retinal bipolar cells: 581 nCPM
enterocytes: 567 nCPM

Immune cell

T-reg: 1.4 nTPM
memory CD4 T-cell: 0.3 nTPM
naive CD8 T-cell: 0.3 nTPM
MAIT T-cell: 0.2 nTPM
memory CD8 T-cell: 0.2 nTPM
gdT-cell: 0.1 nTPM

Brain region

cerebral cortex: 100 nTPM
white matter: 71 nTPM
basal ganglia: 61 nTPM
pons: 46 nTPM
hypothalamus: 45 nTPM
amygdala: 45 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MCF2L2.

Disease | AllUniProt

Conditions MCF2L2 is implicated in, by any mechanism.

Type 2 diabetes mellitus (T2D) MIM:125853

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.9
gnomAD pLI: 0
gnomAD missense Z: 0.79
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

guanyl-nucleotide exchange factor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MCF2L2 as an antibody target. Whether an autoantibody or antibody against MCF2L2 could matter depends on whether native MCF2L2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MCF2L2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MCF2L2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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