Seroatlas · Human Serome Atlas

ARHGEF39

Rho guanine nucleotide exchange factor 39

Also known as: ARG39_HUMAN, C9orf100, FLJ14642

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N4T4
Gene: ARHGEF39
Ensembl: ENSG00000137135
Chromosome: 9
Canonical length: 335 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable guanyl-nucleotide exchange factor activity. Involved in positive regulation of cell migration. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

335 residues, UniProt reviewed canonical sequence.

>Q8N4T4|ARHGEF39
     1  MELSCPGSRC PVQEQRARWE RKRACTAREL LETERRYQEQ LGLVATYFLG ILKAKGTLRP
    61  PERQALFGSW ELIYGASQEL LPYLEGGCWG QGLEGFCRHL ELYNQFAANS ERSQTTLQEQ
   121  LKKNKGFRRF VRLQEGRPEF GGLQLQDLLP LPLQRLQQYE NLVVALAENT GPNSPDHQQL
   181  TRAARLISET AQRVHTIGQK QKNDQHLRRV QALLSGRQAK GLTSGRWFLR QGWLLVVPPH
   241  GEPRPRMFFL FTDVLLMAKP RPPLHLLRSG TFACKALYPM AQCHLSRVFG HSGGPCGGLL
   301  SLSFPHEKLL LMSTDQEELS RWYHSLTWAI SSQKN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARHGEF39 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 12 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 12 nTPM
colon: 4.1 nTPM
urinary bladder: 3.1 nTPM
adipose tissue: 2.9 nTPM
stomach: 2.9 nTPM
prostate: 2.5 nTPM

Single-cell type

early spermatids: 133 nCPM
cardiomyocytes: 125 nCPM
adipocytes: 73 nCPM
epicardial cells: 55 nCPM
late spermatids: 51 nCPM
late primary spermatocytes: 24 nCPM

Immune cell

MAIT T-cell: 0.7 nTPM
gdT-cell: 0.5 nTPM
memory CD8 T-cell: 0.5 nTPM
NK-cell: 0.4 nTPM
T-reg: 0.4 nTPM
basophil: 0.3 nTPM

Brain region

cerebellum: 2.8 nTPM
choroid plexus: 1.5 nTPM
cerebral cortex: 1.4 nTPM
thalamus: 1.4 nTPM
white matter: 1.4 nTPM
pons: 1.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.28
gnomAD pLI: 0
gnomAD missense Z: 0.57
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

Dbl homology domain
Pleckstrin homology domain
PH-like domain superfamily
Dbl homology (DH) domain superfamily
PH domain
RhoGEF domain
Rho guanine nucleotide exchange factor 39

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARHGEF39 as an antibody target. Whether an autoantibody or antibody against ARHGEF39 could matter depends on whether native ARHGEF39 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARHGEF39 is annotated at the cell surface, where native ARHGEF39 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ARHGEF39 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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