Seroatlas · Human Serome Atlas

ARHGEF18

Rho guanine nucleotide exchange factor 18

Also known as: ARHGI_HUMAN, KIAA0521, MGC15913, P114-RhoGEF, p114RhoGEF

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6ZSZ5
Gene
ARHGEF18
Ensembl
ENSG00000104880
Chromosome
19
Canonical length
1361 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Plasma membrane,Cytosol

OverviewNCBI Gene

Rho GTPases are GTP binding proteins that regulate a wide spectrum of cellular functions. These cellular processes include cytoskeletal rearrangements, gene transcription, cell growth and motility. Activation of Rho GTPases is under the direct control of guanine nucleotide exchange factors (GEFs). The protein encoded by this gene is a guanine nucleotide exchange factor and belongs to the Rho GTPase GEF family. Family members share a common feature, a Dbl (DH) homology domain followed by a pleckstrin (PH) homology domain. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Nov 2018]

Canonical amino-acid sequenceUniProt

1361 residues, UniProt reviewed canonical sequence.

>Q6ZSZ5|ARHGEF18
     1  MGDDQEDDFP RRLSESMEDL SLDLGALQGS EYLQDLGLGA PSHSQPGETP DSRPTGEEPG
    61  RDSLFSSLAG SQDLSRRRSW ERSRSCSESW RRLSLDASAV DEEPCLPRTL ASLALNLPGG
   121  GLKTWTQGCL SGGGTPAESP GKECDSPKKR GRSRSVPVSF YEIRSPEISP GLEVPTPPVQ
   181  GLEPPVLECM EKDHVEPDHV LIVQQVLQEL RQYHGARQRA CMSASPGGAH SNLTWFEFLS
   241  ESEDGAGKNE KSDKSTSVKR RLSCLRSRVT RQKEKGKSPA HLKDKGQDAR ERRECVNGHQ
   301  LLQGTFSGPS SCPLCGKPFL SSASLKEHPR GTLLSDGSPA LSRNVGMTVS QKGGPQPTPS
   361  PAGPGTQLGP ITGEMDEADS AFLKFKQTAD DSLSLTSPNT ESIFVEDPYT ASLRSEIESD
   421  GHEFEAESWS LAVDAAYAKK QKREVVKRQD VLYELMQTEV HHVRTLKIML KVYSRALQEE
   481  LQFSSKAIGR LFPCADDLLE THSHFLARLK ERRQESLEEG SDRNYVIQKI GDLLVQQFSG
   541  ENGERMKEKY GVFCSGHNEA VSHYKLLLQQ NKKFQNLIKK IGNFSIVRRL GVQECILLVT
   601  QRITKYPVLV ERIIQNTEAG TEDYEDLTQA LNLIKDIISQ VDAKVSECEK GQRLREIAGK
   661  MDLKSSSKLK NGLTFRKEDM LQRQLHLEGM LCWKTTSGRL KDILAILLTD VLLLLQEKDQ
   721  KYVFASVDSK PPVISLQKLI VREVANEEKA MFLISASLQG PEMYEIYTSS KEDRNAWMAH
   781  IQRAVESCPD EEEGPFSLPE EERKVVEARA TRLRDFQERL SMKDQLIAQS LLEKQQIYLE
   841  MAEMGGLEDL PQPRGLFRGG DPSETLQGEL ILKSAMSEIE GIQSLICRQL GSANGQAEDG
   901  GSSTGPPRRA ETFAGYDCTN SPTKNGSFKK KVSSTDPRPR DWRGPPNSPD LKLSDSDIPG
   961  SSEESPQVVE APGTESDPRL PTVLESELVQ RIQTLSQLLL NLQAVIAHQD SYVETQRAAI
  1021  QEREKQFRLQ STRGNLLLEQ ERQRNFEKQR EERAALEKLQ SQLRHEQQRW ERERQWQHQE
  1081  LERAGARLQE REGEARQLRE RLEQERAELE RQRQAYQHDL ERLREAQRAV ERERERLELL
  1141  RRLKKQNTAP GALPPDTLAE AQPPSHPPSF NGEGLEGPRV SMLPSGVGPE YAERPEVARR
  1201  DSAPTENRLA KSDVPIQLLS ATNQFQRQAA VQQQIPTKLA ASTKGGKDKG GKSRGSQRWE
  1261  SSASFDLKQQ LLLNKLMGKD ESTSRNRRSL SPILPGRHSP APPPDPGFPA PSPPPADSPS
  1321  EGFSLKAGGT ALLPGPPAPS PLPATPLSAK EDASKEDVIF F

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARHGEF18 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.52
Highest tissue expression
35 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 35 nTPM
  • small intestine: 32 nTPM
  • thymus: 31 nTPM
  • lymph node: 28 nTPM
  • colon: 26 nTPM
  • bone marrow: 26 nTPM

Single-cell type

  • thymocytes: 627 nCPM
  • b-cells: 600 nCPM
  • monocyte progenitors: 492 nCPM
  • neutrophil progenitors: 402 nCPM
  • neutrophils: 336 nCPM
  • esophageal apical cells: 270 nCPM

Immune cell

  • eosinophil: 23 nTPM
  • neutrophil: 13 nTPM
  • naive B-cell: 12 nTPM
  • memory B-cell: 8.9 nTPM
  • non-classical monocyte: 7 nTPM
  • basophil: 6.4 nTPM

Brain region

  • white matter: 36 nTPM
  • basal ganglia: 33 nTPM
  • midbrain: 32 nTPM
  • cerebral cortex: 31 nTPM
  • medulla oblongata: 31 nTPM
  • thalamus: 30 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ARHGEF18.

Disease | AllUniProt

Conditions ARHGEF18 is implicated in, by any mechanism.

Disease | GeneticClinVar

29 pathogenic / likely-pathogenic of 1,112 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.46
gnomAD pLI
0
gnomAD missense Z
2.25
DepMap mean gene effect
0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ARHGEF18 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARHGEF18 as an antibody target. Whether an autoantibody or antibody against ARHGEF18 could matter depends on whether native ARHGEF18 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARHGEF18 is annotated at the cell surface, where native ARHGEF18 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ARHGEF18 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ARHGEF18. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...