Seroatlas · Human Serome Atlas

ARHGEF10L

Rho guanine nucleotide exchange factor 10-like protein

Also known as: ARGAL_HUMAN, FLJ10521, KIAA1626

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9HCE6
Gene: ARHGEF10L
Ensembl: ENSG00000074964
Chromosome: 1
Canonical length: 1279 aa
Protein class: Predicted intracellular proteins
Subcellular location: Golgi apparatus,Vesicles,Cytosol

OverviewNCBI Gene

This gene belongs to the RhoGEF subfamily of RhoGTPases. Members of this subfamily are activated by specific guanine nucleotide exchange factors (GEFs) and are involved in signal transduction. The encoded protein shows cytosolic distribution. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2016]

Canonical amino-acid sequenceUniProt

1279 residues, UniProt reviewed canonical sequence.

>Q9HCE6|ARHGEF10L
     1  MASSNPPPQP AIGDQLVPGV PGPSSEAEDD PGEAFEFDDS DDEEDTSAAL GVPSLAPERD
    61  TDPPLIHLDS IPVTDPDPAA APPGTGVPAW VSNGDAADAA FSGARHSSWK RKSSRRIDRF
   121  TFPALEEDVI YDDVPCESPD AHQPGAERNL LYEDAHRAGA PRQAEDLGWS SSEFESYSED
   181  SGEEAKPEVE VEPAKHRVSF QPKLSPDLTR LKERYARTKR DILALRVGGR DMQELKHKYD
   241  CKMTQLMKAA KSGTKDGLEK TRMAVMRKVS FLHRKDVLGD SEEEDMGLLE VSVSDIKPPA
   301  PELGPMPEGL SPQQVVRRHI LGSIVQSEGS YVESLKRILQ DYRNPLMEME PKALSARKCQ
   361  VVFFRVKEIL HCHSMFQIAL SSRVAEWDST EKIGDLFVAS FSKSMVLDVY SDYVNNFTSA
   421  MSIIKKACLT KPAFLEFLKR RQVCSPDRVT LYGLMVKPIQ RFPQFILLLQ DMLKNTPRGH
   481  PDRLSLQLAL TELETLAEKL NEQKRLADQV AEIQQLTKSV SDRSSLNKLL TSGQRQLLLC
   541  ETLTETVYGD RGQLIKSKER RVFLLNDMLV CANINFKPAN HRGQLEISSL VPLGPKYVVK
   601  WNTALPQVQV VEVGQDGGTY DKDNVLIQHS GAKKASASGQ AQNKVYLGPP RLFQELQDLQ
   661  KDLAVVEQIT LLISTLHGTY QNLNMTVAQD WCLALQRLMR VKEEEIHSAN KCRLRLLLPG
   721  KPDKSGRPIS FMVVFITPNP LSKISWVNRL HLAKIGLREE NQPGWLCPDE DKKSKAPFWC
   781  PILACCIPAF SSRALSLQLG ALVHSPVNCP LLGFSAVSTS LPQGYLWVGG GQEGAGGQVE
   841  IFSLNRPSPR TVKSFPLAAP VLCMEYIPEL EEEAESRDES PTVADPSATV HPTICLGLQD
   901  GSILLYSSVD TGTQCLVSCR SPGLQPVLCL RHSPFHLLAG LQDGTLAAYP RTSGGVLWDL
   961  ESPPVCLTVG PGPVRTLLSL EDAVWASCGP RVTVLEATTL QPQQSFEAHQ DEAVSVTHMV
  1021  KAGSGVWMAF SSGTSIRLFH TETLEHLQEI NIATRTTFLL PGQKHLCVTS LLICQGLLWV
  1081  GTDQGVIVLL PVPRLEGIPK ITGKGMVSLN GHCGPVAFLA VATSILAPDI LRSDQEEAEG
  1141  PRAEEDKPDG QAHEPMPDSH VGRELTRKKG ILLQYRLRST AHLPGPLLSM REPAPADGAA
  1201  LEHSEEDGSI YEMADDPDIW VRSRPCARDA HRKEICSVAI ISGGQGYRNF GSALGSSGRQ
  1261  APCGETDSTL LIWQVPLML

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARHGEF10L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 82 nTPM

Expression across tissuesHPA

Tissue

liver: 82 nTPM
blood vessel: 82 nTPM
cerebellum: 76 nTPM
skeletal muscle: 62 nTPM
pancreas: 42 nTPM
skin: 39 nTPM

Single-cell type

esophageal apical cells: 434 nCPM
renal connecting tubule cells: 328 nCPM
tuft cells: 277 nCPM
renal collecting duct principal cells: 237 nCPM
hepatocytes: 229 nCPM
papillary tip epithelial cells: 202 nCPM

Immune cell

classical monocyte: 19 nTPM
intermediate monocyte: 18 nTPM
myeloid DC: 13 nTPM
total PBMC: 7.6 nTPM
non-classical monocyte: 4.8 nTPM
neutrophil: 0.3 nTPM

Brain region

cerebellum: 88 nTPM
pons: 48 nTPM
midbrain: 48 nTPM
thalamus: 46 nTPM
medulla oblongata: 40 nTPM
choroid plexus: 37 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ARHGEF10L.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 253 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Cerebral visual impairment and intellectual disability

Disease | ImmuneIEDB

Conditions an epitope on ARHGEF10L was assayed in.

viral infectious disease T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.44
gnomAD pLI: 0
gnomAD missense Z: 1.51
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ARHGEF10L in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARHGEF10L as an antibody target. Whether an autoantibody or antibody against ARHGEF10L could matter depends on whether native ARHGEF10L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARHGEF10L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ARHGEF10L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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