Seroatlas · Human Serome Atlas

TIAM2

Rho guanine nucleotide exchange factor TIAM2

Also known as: STEF, TIAM2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IVF5
Gene: TIAM2
Ensembl: ENSG00000146426
Chromosome: 6
Canonical length: 1701 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli fibrillar center,Cytosol

OverviewNCBI Gene

This gene encodes a guanine nucleotide exchange factor. A highly similar mouse protein specifically activates ras-related C3 botulinum substrate 1, converting this Rho-like guanosine triphosphatase (GTPase) from a guanosine diphosphate-bound inactive state to a guanosine triphosphate-bound active state. The encoded protein may play a role in neural cell development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

1701 residues, UniProt reviewed canonical sequence.

>Q8IVF5|TIAM2
     1  MGNSDSQYTL QGSKNHSNTI TGAKQIPCSL KIRGIHAKEE KSLHGWGHGS NGAGYKSRSL
    61  ARSCLSHFKS NQPYASRLGG PTCKVSRGVA YSTHRTNAPG KDFQGISAAF STENGFHSVG
   121  HELADNHITS RDCNGHLLNC YGRNESIAST PPGEDRKSPR VLIKTLGKLD GCLRVEFHNG
   181  GNPSKVPAED CSEPVQLLRY SPTLASETSP VPEARRGSSA DSLPSHRPSP TDSRLRSSKG
   241  SSLSSESSWY DSPWGNAGEL SEAEGSFLAP GMPDPSLHAS FPPGDAKKPF NQSSSLSSLR
   301  ELYKDANLGS LSPSGIRLSD EYMGTHASLS NRVSFASDID VPSRVAHGDP IQYSSFTLPC
   361  RKPKAFVEDT AKKDSLKARM RRISDWTGSL SRKKRKLQEP RSKEGSDYFD SRSDGLNTDV
   421  QGSSQASAFL WSGGSTQILS QRSESTHAIG SDPLRQNIYE NFMRELEMSR TNTENIETST
   481  ETAESSSESL SSLEQLDLLF EKEQGVVRKA GWLFFKPLVT VQKERKLELV ARRKWKQYWV
   541  TLKGCTLLFY ETYGKNSMDQ SSAPRCALFA EDSIVQSVPE HPKKENVFCL SNSFGDVYLF
   601  QATSQTDLEN WVTAVHSACA SLFAKKHGKE DTLRLLKNQT KNLLQKIDMD SKMKKMAELQ
   661  LSVVSDPKNR KAIENQIQQW EQNLEKFHMD LFRMRCYLAS LQGGELPNPK SLLAAASRPS
   721  KLALGRLGIL SVSSFHALVC SRDDSALRKR TLSLTQRGRN KKGIFSSLKG LDTLARKGKE
   781  KRPSITQVDE LLHIYGSTVD GVPRDNAWEI QTYVHFQDNH GVTVGIKPEH RVEDILTLAC
   841  KMRQLEPSHY GLQLRKLVDD NVEYCIPAPY EYMQQQVYDE IEVFPLNVYD VQLTKTGSVC
   901  DFGFAVTAQV DERQHLSRIF ISDVLPDGLA YGEGLRKGNE IMTLNGEAVS DLDLKQMEAL
   961  FSEKSVGLTL IARPPDTKAT LCTSWSDSDL FSRDQKSLLP PPNQSQLLEE FLDNFKKNTA
  1021  NDFSNVPDIT TGLKRSQTDG TLDQVSHREK MEQTFRSAEQ ITALCRSFND SQANGMEGPR
  1081  ENQDPPPRSL ARHLSDADRL RKVIQELVDT EKSYVKDLSC LFELYLEPLQ NETFLTQDEM
  1141  ESLFGSLPEM LEFQKVFLET LEDGISASSD FNTLETPSQF RKLLFSLGGS FLYYADHFKL
  1201  YSGFCANHIK VQKVLERAKT DKAFKAFLDA RNPTKQHSST LESYLIKPVQ RVLKYPLLLK
  1261  ELVSLTDQES EEHYHLTEAL KAMEKVASHI NEMQKIYEDY GTVFDQLVAE QSGTEKEVTE
  1321  LSMGELLMHS TVSWLNPFLS LGKARKDLEL TVFVFKRAVI LVYKENCKLK KKLPSNSRPA
  1381  HNSTDLDPFK FRWLIPISAL QVRLGNPAGT ENNSIWELIH TKSEIEGRPE TIFQLCCSDS
  1441  ESKTNIVKVI RSILRENFRR HIKCELPLEK TCKDRLVPLK NRVPVSAKLA SSRSLKVLKN
  1501  SSSNEWTGET GKGTLLDSDE GSLSSGTQSS GCPTAEGRQD SKSTSPGKYP HPGLADFADN
  1561  LIKESDILSD EDDDHRQTVK QGSPTKDIEI QFQRLRISED PDVHPEAEQQ PGPESGEGQK
  1621  GGEQPKLVRG HFCPIKRKAN STKRDRGTLL KAQIRHQSLD SQSENATIDL NSVLEREFSV
  1681  QSLTSVVSEE CFYETESHGK S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TIAM2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 12 nTPM

Expression across tissuesHPA

Tissue

testis: 12 nTPM
cerebral cortex: 12 nTPM
duodenum: 6 nTPM
small intestine: 5.9 nTPM
thyroid gland: 5 nTPM
cerebellum: 4.7 nTPM

Single-cell type

cone photoreceptor cells: 553 nCPM
late spermatids: 479 nCPM
myonuclei: 419 nCPM
pituitary stem cells: 361 nCPM
enterocytes: 265 nCPM
cardiomyocytes: 259 nCPM

Immune cell

non-classical monocyte: 9.5 nTPM
neutrophil: 6.4 nTPM
eosinophil: 2.1 nTPM
intermediate monocyte: 2 nTPM
memory B-cell: 2 nTPM
T-reg: 1.2 nTPM

Brain region

cerebral cortex: 36 nTPM
white matter: 22 nTPM
cerebellum: 22 nTPM
basal ganglia: 22 nTPM
amygdala: 14 nTPM
hippocampal formation: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.43
gnomAD pLI: 0
gnomAD missense Z: 1.24
DepMap mean gene effect: 0.12
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TIAM2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TIAM2 as an antibody target. Whether an autoantibody or antibody against TIAM2 could matter depends on whether native TIAM2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TIAM2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TIAM2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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