Seroatlas · Human Serome Atlas

ALS2CL

ALS2 C-terminal-like protein

Also known as: AL2CL_HUMAN, DKFZp686I0110, FLJ36525, RN49018

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q60I27
Gene: ALS2CL
Ensembl: ENSG00000178038
Chromosome: 3
Canonical length: 953 aa
Protein class: Predicted intracellular proteins
Quaternary structure: Homodimer

OverviewNCBI Gene

Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to be involved in endosomal transport. Predicted to act upstream of or within protein localization. Predicted to be located in cytosol. Predicted to be active in cytoplasmic vesicle. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

953 residues, UniProt reviewed canonical sequence.

>Q60I27|ALS2CL
     1  MCNPEEAALL RLEEVFSATL AHVNSLVLQP LLPAAPDPSD PWGRECLRLL QQLHKSSQQL
    61  WEVTEESLHS LQERLRYPDS TGLESLLLLR GADRVLQAHI EYIESYTSCM VVQAFQKAAK
   121  RRSEYWRGQR KALRQLLSGV SSEGSVGASL GQALHQPLAH HVQQYVLLLL SLGDTIGEHH
   181  PTRELVVNAV TLFGNLQSFM KQELDQAVAT QALWHTLRGR LRDVLCTPAH RLLQDSQDVP
   241  VTVAPLRAER VLLFDDALVL LQGHNVHTFD LKLVWVDPGQ DGCTFHLLTP EEEFSFCAKD
   301  SQGQAVWQWK VTWAVHQALH GKKDFPVLGA GLEPSQPPDC RCAEYTFQAE GRLCQATYEG
   361  EWCRGRPHGK GTLKWPDGRN HVGNFCQGLE HGFGIRLLPQ ASEDKFDCYK CHWREGSMCG
   421  YGICEYSTDE VYKGYFQEGL RHGFGVLESG PQAPQPFRYT GHWERGQRSG YGIEEDGDRG
   481  ERYIGMWQAG QRHGPGVMVT QAGVCYQGTF QADKTVGPGI LLSEDDSLYE GTFTRDLTLM
   541  GKGKVTFPNG FTLEGSFGSG AGRGLHTQGV LDTAALPPDP SSTCKRQLGV GAFPVESRWQ
   601  GVYSPFRDFV CAGCPRDLQE ALLGFDVQSS RELRRSQDYL SCERTHPEDS VGSMEDILEE
   661  LLQHREPKAL QLYLRKALSN SLHPLGKLLR TLMLTFQATY AGVGANKHLQ ELAQEEVKQH
   721  AQELWAAYRG LLRVALERKG QALEEDEDTE TRDLQVHGLV LPLMLPSFYS ELFTLYLLLH
   781  EREDSFYSQG IANLSLFPDT QLLEFLDVQK HLWPLKDLTL TSNQRYSLVR DKCFLSATEC
   841  LQKIMTTVDP REKLEVLERT YGEIEGTVSR VLGREYKLPM DDLLPLLIYV VSRARIQHLG
   901  AEIHLIRDMM DPNHTGGLYD FLLTALESCY EHIQKEDMRL HRLPGHWHSR ELW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ALS2CL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 35 nTPM

Expression across tissuesHPA

Tissue

esophagus: 35 nTPM
kidney: 32 nTPM
skin: 31 nTPM
vagina: 18 nTPM
cervix: 16 nTPM
thyroid gland: 14 nTPM

Single-cell type

podocytes: 1,309 nCPM
esophageal apical cells: 409 nCPM
esophageal suprabasal cells: 219 nCPM
alveolar cells type 1: 89 nCPM
esophageal basal cells: 72 nCPM
papillary tip epithelial cells: 64 nCPM

Immune cell

naive CD4 T-cell: 0.7 nTPM
memory CD4 T-cell: 0.5 nTPM
T-reg: 0.4 nTPM
myeloid DC: 0.2 nTPM
classical monocyte: 0.1 nTPM
memory CD8 T-cell: 0.1 nTPM

Brain region

cerebellum: 5.4 nTPM
cerebral cortex: 5.3 nTPM
pons: 4.7 nTPM
medulla oblongata: 4.1 nTPM
basal ganglia: 3.5 nTPM
hypothalamus: 3.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.08
gnomAD pLI: 0
gnomAD missense Z: 0.17
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

endosomal transport

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ALS2CL in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ALS2CL as an antibody target. Whether an autoantibody or antibody against ALS2CL could matter depends on whether native ALS2CL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ALS2CL is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ALS2CL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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