Seroatlas · Human Serome Atlas

SPATA13

Spermatogenesis-associated protein 13

Also known as: ARHGEF29, ASEF2, FLJ31208, SPT13_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96N96
Gene
SPATA13
Ensembl
ENSG00000182957
Chromosome
13
Canonical length
652 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

Enables guanyl-nucleotide exchange factor activity and identical protein binding activity. Involved in cell migration; plasma membrane bounded cell projection assembly; and regulation of cell migration. Located in several cellular components, including filopodium; lamellipodium; and ruffle membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

652 residues, UniProt reviewed canonical sequence.

>Q96N96|SPATA13
     1  MTSASPEDQN APVGCPKGAR RRRPISVIGG VSLYGTNQTE ELDNLLTQPA SRPPMPAHQV
    61  PPYKAVSARF RPFTFSQSTP IGLDRVGRRR QMRASNVSSD GGTEPSALVD DNGSEEDFSY
   121  EDLCQASPRY LQPGGEQLAI NELISDGNVV CAEALWDHVT MDDQELGFKA GDVIQVLEAS
   181  NKDWWWGRSE DKEAWFPASF VRLRVNQEEL SENSSSTPSE EQDEEASQSR HRHCENKQQM
   241  RTNVIREIMD TERVYIKHLR DICEGYIRQC RKHTGMFTVA QLATIFGNIE DIYKFQRKFL
   301  KDLEKQYNKE EPHLSEIGSC FLQNQEGFAI YSEYCNNHPG ACLELANLMK QGKYRHFFEA
   361  CRLLQQMIDI AIDGFLLTPV QKICKYPLQL AELLKYTTQE HGDYSNIKAA YEAMKNVACL
   421  INERKRKLES IDKIARWQVS IVGWEGLDIL DRSSELIHSG ELTKITKQGK SQQRTFFLFD
   481  HQLVSCKKDL LRRDMLYYKG RLDMDEMELV DLGDGRDKDC NLSVKNAFKL VSRTTDEVYL
   541  FCAKKQEDKA RWLQACADER RRVQEDKEMG MEISENQKKL AMLNAQKAGH GKSKGYNRCP
   601  VAPPHQGLHP IHQRHITMPT SVPQQQVFGL AEPKRKSSLF WHTFNRLTPF RK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPATA13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.4
Highest tissue expression
62 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 62 nTPM
  • pancreas: 37 nTPM
  • bone marrow: 29 nTPM
  • spinal cord: 29 nTPM
  • liver: 23 nTPM
  • lymph node: 22 nTPM

Single-cell type

  • choroid plexus epithelial cells: 781 nCPM
  • ependymal cells: 411 nCPM
  • oligodendrocytes: 251 nCPM
  • microglia: 242 nCPM
  • bergmann glia: 193 nCPM
  • astrocytes: 139 nCPM

Immune cell

  • neutrophil: 40 nTPM
  • memory CD8 T-cell: 35 nTPM
  • gdT-cell: 34 nTPM
  • naive CD8 T-cell: 31 nTPM
  • naive CD4 T-cell: 30 nTPM
  • T-reg: 30 nTPM

Brain region

  • medulla oblongata: 98 nTPM
  • white matter: 85 nTPM
  • choroid plexus: 77 nTPM
  • pons: 74 nTPM
  • midbrain: 72 nTPM
  • basal ganglia: 72 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.46
gnomAD pLI
0
gnomAD missense Z
2.03
DepMap mean gene effect
-0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SPATA13 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPATA13 as an antibody target. Whether an autoantibody or antibody against SPATA13 could matter depends on whether native SPATA13 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPATA13 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPATA13 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SPATA13. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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