Seroatlas · Human Serome Atlas

ECT2L

Epithelial cell-transforming sequence 2 oncogene-like

Also known as: ARHGEF32, C6orf91, ECT2L_HUMAN, FBXO49, LFDH

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q008S8
Gene: ECT2L
Ensembl: ENSG00000203734
Chromosome: 6
Canonical length: 904 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles

OverviewNCBI Gene

Predicted to enable guanyl-nucleotide exchange factor activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

904 residues, UniProt reviewed canonical sequence.

>Q008S8|ECT2L
     1  MESFHTRFSA WTPFSNKSLN RQLFQERVAL ISHWFDLWTN KQRQEFLFAI FLRCTKSQLR
    61  FVQDWFSERM QVAKVDFSTV LPRFISLYIF SFLSPKDLCA AAQVSWPWKF LTEQDCLWMP
   121  KCVKFGWFLP YTPTDNEYGA WKRHYIACVS HLDWLTPREA AATYGTLNEP KTEDEELLER
   181  QREKCLRKRI WEKIALRKKE LFKVRPPWVS GTCCSSVLKP RCQPRLSQTV RERVGLHEAL
   241  EKQLVLTSLE TLPKRSNISG SHSYPLLSKK NWHGVHKNDD RSSYALRPHF MLISSRIPAY
   301  EMVMESVKAG VVSVVYEHSV TLESLLYLIE KALDGQKAQS IGIFSDGDSR EINLLQGYKI
   361  GVKNLLRPEV RDFWEKLGSY VATEEEGGHV DFFVPLGASE AGIEVLSQLS QLTGTFFTAP
   421  TGIATGSYQH ILSDWLGSQW GKAPSSIYFC ESKLQTWSSF TDFLEETLKT VRKQLYPFFK
   481  ELQKSISGRM IGQFMFDTMG MTNILNNQDT AQALADGLME LSKEDSERNV VEDNSWDTKS
   541  RLSKNDLNFE ALINLERILQ KDSAEKRARV VRELLQSERK YVQILEIVRD VYVAPLKAAL
   601  SSNRAILSAA NIQIIFCDIL QILSLNRQFL DNLRDRLQEW GPAHCVGEIV TKFGSQLNTY
   661  TNFFNNYPVI LKTIEKCREM IPAFRTFLKR HDKTIVTKML SLPELLLYPS RRFEEYLNLL
   721  YAVRLHTPAE HVDRGDLTTA IDQIKKYKGY IDQMKQNITM KDHLSDIQRI IWGCPTLSEV
   781  NRYLIRVQDV AQLHCCDEEI SFSLRLYEHI HDLSLFLFND ALLVSSRGTS HTPFERTSKT
   841  TYQFIASVAL HRLLIENIPD SKYVKNAFIL QGPKYKWICA TEIEDDKFLW LSVLRNAIKS
   901  SMEK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ECT2L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 8.1 nTPM

Expression across tissuesHPA

Tissue

fallopian tube: 8.1 nTPM
heart muscle: 1.5 nTPM
lung: 1.4 nTPM
choroid plexus: 1.2 nTPM
cervix: 0.4 nTPM
retina: 0.4 nTPM

Single-cell type

cardiomyocytes: 971 nCPM
respiratory ciliated cells: 569 nCPM
fallopian tube ciliated cells: 227 nCPM
ependymal cells: 226 nCPM
endometrial ciliated cells: 79 nCPM
epididymal efferent duct ciliated cells: 78 nCPM

Immune cell

basophil: 0.2 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

medulla oblongata: 6.7 nTPM
choroid plexus: 6.2 nTPM
midbrain: 5.9 nTPM
hippocampal formation: 5.3 nTPM
spinal cord: 5.2 nTPM
amygdala: 5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.5
gnomAD pLI: 0
gnomAD missense Z: 0.11
DepMap mean gene effect: -0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 0% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

guanyl-nucleotide exchange factor activity

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Guanine-nucleotide releasing factor

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ECT2L as an antibody target. Whether an autoantibody or antibody against ECT2L could matter depends on whether native ECT2L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ECT2L is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ECT2L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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