Seroatlas · Human Serome Atlas

ARHGEF19

Rho guanine nucleotide exchange factor 19

Also known as: ARHGJ_HUMAN, FLJ33962, WGEF

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IW93
Gene: ARHGEF19
Ensembl: ENSG00000142632
Chromosome: 1
Canonical length: 802 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear bodies

OverviewNCBI Gene

Guanine nucleotide exchange factors (GEFs) such as ARHGEF19 accelerate the GTPase activity of Rho GTPases (see RHOA, MIM 165390).[supplied by OMIM, Dec 2008]

Canonical amino-acid sequenceUniProt

802 residues, UniProt reviewed canonical sequence.

>Q8IW93|ARHGEF19
     1  MDCGPPATLQ PHLTGPPGTA HHPVAVCQQE SLSFAELPAL KPPSPVCLDL FPVAPEELRA
    61  PGSRWSLGTP APLQGLLWPL SPGGSDTEIT SGGMRPSRAG SWPHCPGAQP PALEGPWSPR
   121  HTQPQRRASH GSEKKSAWRK MRVYQREEVP GCPEAHAVFL EPGQVVQEQA LSTEEPRVEL
   181  SGSTRVSLEG PERRRFSASE LMTRLHSSLR LGRNSAARAL ISGSGTGAAR EGKASGMEAR
   241  SVEMSGDRVS RPAPGDSREG DWSEPRLDTQ EEPPLGSRST NERRQSRFLL NSVLYQEYSD
   301  VASARELRRQ QREEEGPGDE AEGAEEGPGP PRANLSPSSS FRAQRSARGS TFSLWQDIPD
   361  VRGSGVLATL SLRDCKLQEA KFELITSEAS YIHSLSVAVG HFLGSAELSE CLGAQDKQWL
   421  FSKLPEVKST SERFLQDLEQ RLEADVLRFS VCDVVLDHCP AFRRVYLPYV TNQAYQERTY
   481  QRLLLENPRF PGILARLEES PVCQRLPLTS FLILPFQRIT RLKMLVENIL KRTAQGSEDE
   541  DMATKAFNAL KELVQECNAS VQSMKRTEEL IHLSKKIHFE GKIFPLISQA RWLVRHGELV
   601  ELAPLPAAPP AKLKLSSKAV YLHLFNDCLL LSRRKELGKF AVFVHAKMAE LQVRDLSLKL
   661  QGIPGHVFLL QLLHGQHMKH QFLLRARTES EKQRWISALC PSSPQEDKEV ISEGEDCPQV
   721  QCVRTYKALH PDELTLEKTD ILSVRTWTSD GWLEGVRLAD GEKGWVPQAY VEEISSLSAR
   781  LRNLRENKRV TSATSKLGEA PV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARHGEF19 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 27 nTPM

Expression across tissuesHPA

Tissue

skin: 27 nTPM
salivary gland: 16 nTPM
esophagus: 15 nTPM
thyroid gland: 11 nTPM
vagina: 11 nTPM
cervix: 10 nTPM

Single-cell type

paneth cells: 27 nCPM
esophageal basal cells: 23 nCPM
prostatic hillock cells: 21 nCPM
esophageal apical cells: 21 nCPM
respiratory deuterosomal cells: 21 nCPM
respiratory basal cells: 19 nCPM

Immune cell

gdT-cell: 0.9 nTPM
MAIT T-cell: 0.9 nTPM
memory CD4 T-cell: 0.8 nTPM
naive CD4 T-cell: 0.8 nTPM
NK-cell: 0.8 nTPM
memory B-cell: 0.7 nTPM

Brain region

hypothalamus: 1.3 nTPM
medulla oblongata: 1.3 nTPM
amygdala: 1.2 nTPM
choroid plexus: 1.1 nTPM
midbrain: 1.1 nTPM
cerebral cortex: 1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.15
gnomAD pLI: 0
gnomAD missense Z: 0.97
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

cytosol

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARHGEF19 as an antibody target. Whether an autoantibody or antibody against ARHGEF19 could matter depends on whether native ARHGEF19 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARHGEF19 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ARHGEF19 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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