Seroatlas · Human Serome Atlas

ARHGEF11

Rho guanine nucleotide exchange factor 11

Also known as: ARHGB_HUMAN, GTRAP48, KIAA0380, PDZ-RHOGEF

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O15085
Gene: ARHGEF11
Ensembl: ENSG00000132694
Chromosome: 1
Canonical length: 1522 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Plasma membrane

OverviewNCBI Gene

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

1522 residues, UniProt reviewed canonical sequence.

>O15085|ARHGEF11
     1  MSVRLPQSID RLSSLSSLGD SAPERKSPSH HRQPSDASET TGLVQRCVII QKDQHGFGFT
    61  VSGDRIVLVQ SVRPGGAAMK AGVKEGDRII KVNGTMVTNS SHLEVVKLIK SGAYVALTLL
   121  GSSPSSMGIS GLQQDPSPAG APRITSVIPS PPPPPPLPPP QRITGPKPLQ DPEVQKHATQ
   181  ILRNMLRQEE KELQDILPLY GDTSQRPSEG RLSLDSQEGD SGLDSGTERF PSLSESLMNR
   241  NSVLSDPGLD SPRTSPVIMA RVAQHHRRQG SDAAVPSTGD QGVDQSPKPL IIGPEEDYDP
   301  GYFNNESDII FQDLEKLKSR PAHLGVFLRY IFSQADPSPL LFYLCAEVYQ QASPKDSRSL
   361  GKDIWNIFLE KNAPLRVKIP EMLQAEIDSR LRNSEDARGV LCEAQEAAMP EIQEQIHDYR
   421  TKRTLGLGSL YGENDLLDLD GDPLRERQVA EKQLAALGDI LSKYEEDRSA PMDFALNTYM
   481  SHAGIRLREA RPSNTAEKAQ SAPDKDKWLP FFPKTKKSSN SKKEKDALED KKRNPILKYI
   541  GKPKSSSQST FHIPLSPVEV KPGNVRNIIQ HFENNQQYDA PEPGTQRLST GSFPEDLLES
   601  DSSRSEIRLG RSESLKGREE MKRSRKAENV PRSRSDVDMD AAAEATRLHQ SASSSTSSLS
   661  TRSLENPTPP FTPKMGRRSI ESPSLGFCTD TLLPHLLEDD LGQLSDLEPE PDAQNWQHTV
   721  GKDVVAGLTQ REIDRQEVIN ELFVTEASHL RTLRVLDLIF YQRMKKENLM PREELARLFP
   781  NLPELIEIHN SWCEAMKKLR EEGPIIKEIS DLMLARFDGP AREELQQVAA QFCSYQSIAL
   841  ELIKTKQRKE SRFQLFMQEA ESHPQCRRLQ LRDLIISEMQ RLTKYPLLLE SIIKHTEGGT
   901  SEHEKLCRAR DQCREILKYV NEAVKQTENR HRLEGYQKRL DATALERASN PLAAEFKSLD
   961  LTTRKMIHEG PLTWRISKDK TLDLHVLLLE DLLVLLQKQD EKLLLKCHSK TAVGSSDSKQ
  1021  TFSPVLKLNA VLIRSVATDK RAFFIICTSK LGPPQIYELV ALTSSDKNTW MELLEEAVRN
  1081  ATRHPGAAPM PVHPPPPGPR EPAQQGPTPS RVELDDSDVF HGEPEPEELP GGTGSQQRVQ
  1141  GKHQVLLEDP EQEGSAEEEE LGVLPCPSTS LDGENRGIRT RNPIHLAFPG PLFMEGLADS
  1201  ALEDVENLRH LILWSLLPGH TMETQAAQEP EDDLTPTPSV ISVTSHPWDP GSPGQAPPGG
  1261  EGDNTQLAGL EGERPEQEDM GLCSLEHLPP RTRNSGIWES PELDRNLAED ASSTEAAGGY
  1321  KVVRKAEVAG SKVVPALPES GQSEPGPPEV EGGTKATGNC FYVSMPSGPP DSSTDHSEAP
  1381  MSPPQPDSLP AGQTEPQPQL QGGNDDPRRP SRSPPSLALR DVGMIFHTIE QLTLKLNRLK
  1441  DMELAHRELL KSLGGESSGG TTPVGSFHTE AARWTDGSLS PPAKEPLASD SRNSHELGPC
  1501  PEDGSDAPLE DSTADAAASP GP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARHGEF11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 24 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 24 nTPM
cerebellum: 21 nTPM
testis: 18 nTPM
cerebral cortex: 16 nTPM
retina: 16 nTPM
small intestine: 14 nTPM

Single-cell type

cone photoreceptor cells: 487 nCPM
tuft cells: 300 nCPM
retinal bipolar cells: 252 nCPM
corticotrophs: 251 nCPM
rod photoreceptor cells: 250 nCPM
sertoli cells: 202 nCPM

Immune cell

neutrophil: 0.9 nTPM
intermediate monocyte: 0.8 nTPM
classical monocyte: 0.4 nTPM
non-classical monocyte: 0.4 nTPM
naive CD8 T-cell: 0.3 nTPM
myeloid DC: 0.2 nTPM

Brain region

cerebral cortex: 79 nTPM
thalamus: 69 nTPM
pons: 60 nTPM
midbrain: 58 nTPM
medulla oblongata: 57 nTPM
hypothalamus: 55 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.22
gnomAD pLI: 1
gnomAD missense Z: 1.63
DepMap mean gene effect: -0.26
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 14% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Dbl homology domain
PDZ domain
Pleckstrin homology domain
PH-like domain superfamily
Regulator of G protein signalling-like domain
RGS domain
Dbl homology (DH) domain superfamily
PDZ superfamily
RGS domain superfamily
ARHGEF1-like, PH domain
RGS, subdomain 2
PDZ domain
RhoGEF domain
Regulator of G protein signalling-like domain
PH domain
Rho guanine nucleotide exchange factor 11, PH domain
Rho guanine nucleotide exchange factor 11, RGS domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ARHGEF11 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARHGEF11 as an antibody target. Whether an autoantibody or antibody against ARHGEF11 could matter depends on whether native ARHGEF11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARHGEF11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ARHGEF11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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