Seroatlas · Human Serome Atlas

ARHGEF2

Rho guanine nucleotide exchange factor 2

Also known as: ARHG2_HUMAN, GEF-H1, GEFH1, KIAA0651, Lfc, LFP40, P40

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q92974
Gene
ARHGEF2
Ensembl
ENSG00000116584
Chromosome
1
Canonical length
986 aa
Protein class
Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins

OverviewNCBI Gene

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate rho-dependent signals. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Jun 2009]

Canonical amino-acid sequenceUniProt

986 residues, UniProt reviewed canonical sequence.

>Q92974|ARHGEF2
     1  MSRIESLTRA RIDRSRELAS KTREKEKMKE AKDARYTNGH LFTTISVSGM TMCYACNKSI
    61  TAKEALICPT CNVTIHNRCK DTLANCTKVK QKQQKAALLK NNTALQSVSL RSKTTIRERP
   121  SSAIYPSDSF RQSLLGSRRG RSSLSLAKSV STTNIAGHFN DESPLGLRRI LSQSTDSLNM
   181  RNRTLSVESL IDEAEVIYSE LMSDFEMDEK DFAADSWSLA VDSSFLQQHK KEVMKQQDVI
   241  YELIQTELHH VRTLKIMTRL FRTGMLEELH LEPGVVQGLF PCVDELSDIH TRFLSQLLER
   301  RRQALCPGST RNFVIHRLGD LLISQFSGPS AEQMCKTYSE FCSRHSKALK LYKELYARDK
   361  RFQQFIRKVT RPAVLKRHGV QECILLVTQR ITKYPLLISR ILQHSHGIEE ERQDLTTALG
   421  LVKELLSNVD EGIYQLEKGA RLQEIYNRMD PRAQTPVPGK GPFGREELLR RKLIHDGCLL
   481  WKTATGRFKD VLVLLMTDVL VFLQEKDQKY IFPTLDKPSV VSLQNLIVRD IANQEKGMFL
   541  ISAAPPEMYE VHTASRDDRS TWIRVIQQSV RTCPSREDFP LIETEDEAYL RRIKMELQQK
   601  DRALVELLRE KVGLFAEMTH FQAEEDGGSG MALPTLPRGL FRSESLESPR GERLLQDAIR
   661  EVEGLKDLLV GPGVELLLTP REPALPLEPD SGGNTSPGVT ANGEARTFNG SIELCRADSD
   721  SSQRDRNGNQ LRSPQEEALQ RLVNLYGLLH GLQAAVAQQD TLMEARFPEG PERREKLCRA
   781  NSRDGEAGRA GAAPVAPEKQ ATELALLQRQ HALLQEELRR CRRLGEERAT EAGSLEARLR
   841  ESEQARALLE REAEEARRQL AALGQTEPLP AEAPWARRPV DPRRRSLPAG DALYLSFNPP
   901  QPSRGTDRLD LPVTTRSVHR NFEDRERQEL GSPEERLQDS SDPDTGSEEE GSSRLSPPHS
   961  PRDFTRMQDI PEETESRDGE AVASES

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARHGEF2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.46
Highest tissue expression
105 nTPM

Expression across tissuesHPA

Tissue

  • spinal cord: 105 nTPM
  • lung: 85 nTPM
  • cerebellum: 76 nTPM
  • spleen: 67 nTPM
  • blood vessel: 65 nTPM
  • cerebral cortex: 59 nTPM

Single-cell type

  • neutrophils: 246 nCPM
  • monocytes: 143 nCPM
  • oligodendrocytes: 140 nCPM
  • tuft cells: 127 nCPM
  • alveolar cells type 1: 112 nCPM
  • myosatellite cells: 95 nCPM

Immune cell

  • neutrophil: 32 nTPM
  • total PBMC: 28 nTPM
  • non-classical monocyte: 22 nTPM
  • classical monocyte: 21 nTPM
  • intermediate monocyte: 18 nTPM
  • myeloid DC: 18 nTPM

Brain region

  • white matter: 212 nTPM
  • medulla oblongata: 150 nTPM
  • basal ganglia: 135 nTPM
  • thalamus: 133 nTPM
  • pons: 130 nTPM
  • cerebral cortex: 129 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ARHGEF2.

Disease | AllUniProt

Conditions ARHGEF2 is implicated in, by any mechanism.

  • Neurodevelopmental disorder with midbrain and hindbrain malformations (NEDMHM) MIM:617523

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 164 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Neurodevelopmental disorder with midbrain and hindbrain malformations

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.16
gnomAD pLI
1
gnomAD missense Z
3.61
DepMap mean gene effect
-0.14
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ARHGEF2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARHGEF2 as an antibody target. Whether an autoantibody or antibody against ARHGEF2 could matter depends on whether native ARHGEF2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARHGEF2 is annotated at the cell surface, where native ARHGEF2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ARHGEF2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ARHGEF2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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