Seroatlas · Human Serome Atlas

PLEKHG3

Pleckstrin homology domain-containing family G member 3

Also known as: ARHGEF43, KIAA0599, PKHG3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A1L390
Gene
PLEKHG3
Ensembl
ENSG00000126822
Chromosome
14
Canonical length
1219 aa
Protein class
Predicted intracellular proteins
Subcellular location
Plasma membrane,Cytosol

OverviewNCBI Gene

Enables actin binding activity. Involved in regulation of cell migration and regulation of establishment of cell polarity. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1219 residues, UniProt reviewed canonical sequence.

>A1L390|PLEKHG3
     1  MPVSTSLHQD GSQERPVSLT STTSSSGSSC DSRSAMEEPS SSEAPAKNGA GSLRSRHLPN
    61  SNNNSSSWLN VKGPLSPFNS RAAAGPAHHK LSYLGRVVRE IVETERMYVQ DLRSIVEDYL
   121  LKIIDTPGLL KPEQVSALFG NIENIYALNS QLLRDLDSCN SDPVAVASCF VERSQEFDIY
   181  TQYCNNYPNS VAALTECMRD KQQAKFFRDR QELLQHSLPL GSYLLKPVQR ILKYHLLLQE
   241  IAKHFDEEED GFEVVEDAID TMTCVAWYIN DMKRRHEHAV RLQEIQSLLI NWKGPDLTTY
   301  GELVLEGTFR VHRVRNERTF FLFDKTLLIT KKRGDHFVYK GNIPCSSLML IESTRDSLCF
   361  TVTHYKHSKQ QYSIQAKTVE EKRNWTHHIK RLILENHHAT IPQKAKEAIL EMDSYYPNRY
   421  RCSPERLKKA WSSQDEVSTN VRQGRRQSEP TKHLLRQLNE KARAAGMKGK GRRESESSRS
   481  SRRPSGRSPT STEKRMSFES ISSLPEVEPD PEAGSEQEVF SAVEGPSAEE TPSDTESPEV
   541  LETQLDAHQG LLGMDPPGDM VDFVAAESTE DLKALSSEEE EEMGGAAQEP ESLLPPSVLD
   601  QASVIAERFV SSFSRRSSVA QEDSKSSGFG SPRLVSRSSS VLSLEGSEKG LARHGSATDS
   661  LSCQLSPEVD ISVGVATEDS PSVNGMEPPS PGCPVEPDRS SCKKKESALS TRDRLLLDKI
   721  KSYYENAEHH DAGFSVRRRE SLSYIPKGLV RNSISRFNSL PRPDPEPVPP VGSKRQVGSR
   781  PTSWALFELP GPSQAVKGDP PPISDAEFRP SSEIVKIWEG MESSGGSPGK GPGQGQANGF
   841  DLHEPLFILE EHELGAITEE SATASPESSS PTEGRSPAHL ARELKELVKE LSSSTQGELV
   901  APLHPRIVQL SHVMDSHVSE RVKNKVYQLA RQYSLRIKSN KPVMARPPLQ WEKVAPERDG
   961  KSPTVPCLQE EAGEPLGGKG KRKPVLSLFD YEQLMAQEHS PPKPSSAGEM SPQRFFFNPS
  1021  AVSQRTTSPG GRPSARSPLS PTETFSWPDV RELCSKYASR DEARRAGGGR PRGPPVNRSH
  1081  SVPENMVEPP LSGRVGRCRS LSTKRGRGGG EAAQSPGPLP QSKPDGGETL YVTADLTLED
  1141  NRRVIVMEKG PLPSPTAGLE ESSGQGPSSP VALLGQVQDF QQSAECQPKE EGSRDPADPS
  1201  QQGRVRNLRE KFQALNSVG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PLEKHG3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.56
Highest tissue expression
69 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 69 nTPM
  • endometrium: 44 nTPM
  • spinal cord: 36 nTPM
  • kidney: 36 nTPM
  • hippocampal formation: 35 nTPM
  • esophagus: 35 nTPM

Single-cell type

  • oligodendrocytes: 143 nCPM
  • renal collecting duct principal cells: 97 nCPM
  • loop of henle epithelial cells: 86 nCPM
  • cardiomyocytes: 80 nCPM
  • ocular epithelial cells: 70 nCPM
  • vascular smooth muscle cells: 68 nCPM

Immune cell

  • neutrophil: 24 nTPM
  • eosinophil: 18 nTPM
  • gdT-cell: 15 nTPM
  • MAIT T-cell: 11 nTPM
  • NK-cell: 9 nTPM
  • basophil: 8.9 nTPM

Brain region

  • white matter: 248 nTPM
  • basal ganglia: 142 nTPM
  • cerebral cortex: 139 nTPM
  • thalamus: 119 nTPM
  • midbrain: 107 nTPM
  • medulla oblongata: 106 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.65
gnomAD pLI
0
gnomAD missense Z
0.44
DepMap mean gene effect
0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PLEKHG3 as an antibody target. Whether an autoantibody or antibody against PLEKHG3 could matter depends on whether native PLEKHG3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PLEKHG3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PLEKHG3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PLEKHG3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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