Seroatlas · Human Serome Atlas

ARHGEF17

Rho guanine nucleotide exchange factor 17

Also known as: ARHGH_HUMAN, KIAA0337, p164-RhoGEF, TEM4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96PE2
Gene: ARHGEF17
Ensembl: ENSG00000110237
Chromosome: 11
Canonical length: 2063 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane,Cytosol

OverviewNCBI Gene

Enables guanyl-nucleotide exchange factor activity. Acts upstream of or within actin cytoskeleton organization. Predicted to be located in cytosol. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

2063 residues, UniProt reviewed canonical sequence.

>Q96PE2|ARHGEF17
     1  MADGAPRPQL YRSVSFKLLE RWSGGPGLRE EDTDTPGLRR RASCRPTTAA RGQPSRRVSK
    61  LASGPLAAPA QPRPLRSLSP SVRQLSRRFD APRLDDGSAG TRDGGVLPAA AEEAAEGPAR
   121  GAWPSVTEMR KLFGGPGSRR PSADSESPGT PSPDGAAWEP PARESRQPPT PPPRTCFPLA
   181  GLRSARPLTG PETEGRLRRP QQQQERAQRP ADGLHSWHIF SQPQAGARAS CSSSSIAASY
   241  PVSRSRAASS SEEEEEGPPQ LPGAQSPAYH GGHSSGSDDD RDGEGGHRWG GRPGLRPGSS
   301  LLDQDCRPDS DGLNLSSMNS AGVSGSPEPP TSPRAPREEG LREWGSGSPP CVPGPQEGLR
   361  PMSDSVGGAF RVAKVSFPSY LASPAGSRGS SRYSSTETLK DDDLWSSRGS GGWGVYRSPS
   421  FGAGEGLLRS QARTRAKGPG GTSRALRDGG FEPEKSRQRK SLSNPDIASE TLTLLSFLRS
   481  DLSELRVRKP GGSSGDRGSN PLDGRDSPSA GGPVGQLEPI PIPAPASPGT RPTLKDLTAT
   541  LRRAKSFTCS EKPMARRLPR TSALKSSSSE LLLTGPGAEE DPLPLIVQDQ YVQEARQVFE
   601  KIQRMGAQQD DGSDAPPGSP DWAGDVTRGQ RSQEELSGPE SSLTDEGIGA DPEPPVAAFC
   661  GLGTTGMWRP LSSSSAQTNH HGPGTEDSLG GWALVSPETP PTPGALRRRR KVPPSGSGGS
   721  ELSNGEAGEA YRSLSDPIPQ RHRAATSEEP TGFSVDSNLL GSLSPKTGLP ATSAMDEGLT
   781  SGHSDWSVGS EESKGYQEVI QSIVQGPGTL GRVVDDRIAG KAPKKKSLSD PSRRGELAGP
   841  GFEGPGGEPI REVEPMLPPS SSEPILVEQR AEPEEPGATR SRAQSERALP EALPPPATAH
   901  RNFHLDPKLA DILSPRLIRR GSKKRPARSS HQELRRDEGS QDQTGSLSRA RPSSRHVRHA
   961  SVPATFMPIV VPEPPTSVGP PVAVPEPIGF PTRAHPTLQA PSLEDVTKQY MLNLHSGEVP
  1021  APVPVDMPCL PLAAPPSAEA KPPEAARPAD EPTPASKCCS KPQVDMRKHV AMTLLDTEQS
  1081  YVESLRTLMQ GYMQPLKQPE NSVLCDPSLV DEIFDQIPEL LEHHEQFLEQ VRHCMQTWHA
  1141  QQKVGALLVQ SFSKDVLVNI YSAYIDNFLN AKDAVRVAKE ARPAFLKFLE QSMRENKEKQ
  1201  ALSDLMIKPV QRIPRYELLV KDLLKHTPED HPDHPLLLEA QRNIKQVAER INKGVRSAEE
  1261  AERHARVLQE IEAHIEGMED LQAPLRRFLR QEMVIEVKAI GGKKDRSLFL FTDLIVCTTL
  1321  KRKSGSLRRS SMSLYTAASV IDTASKYKML WKLPLEDADI IKGASQATNR ENIQKAISRL
  1381  DEDLTTLGQM SKLSESLGFP HQSLDDALRD LSAAMHRDLS EKQALCYALS FPPTKLELCA
  1441  TRPEGTDSYI FEFPHPDARL GFEQAFDEAK RKLASSKSCL DPEFLKAIPI MKTRSGMQFS
  1501  CAAPTLNSCP EPSPEVWVCN SDGYVGQVCL LSLRAEPDVE ACIAVCSARI LCIGAVPGLQ
  1561  PRCHREPPPS LRSPPETAPE PAGPELDVEA AADEEAATLA EPGPQPCLHI SIAGSGLEMT
  1621  PGLGEGDPRP ELVPFDSDSD DESSPSPSGT LQSQASRSTI SSSFGNEETP SSKEATAETT
  1681  SSEEEQEPGF LPLSGSFGPG GPCGTSPMDG RALRRSSHGS FTRGSLEDLL SVDPEAYQSS
  1741  VWLGTEDGCV HVYQSSDSIR DRRNSMKLQH AASVTCILYL NNQVFVSLAN GELVVYQREA
  1801  GHFWDPQNFK SVTLGTQGSP ITKMVSVGGR LWCGCQNRVL VLSPDTLQLE HMFYVGQDSS
  1861  RCVACMVDSS LGVWVTLKGS AHVCLYHPDT FEQLAEVDVT PPVHRMLAGS DAIIRQHKAA
  1921  CLRITALLVC EELLWVGTSA GVVLTMPTSP GTVSCPRAPL SPTGLGQGHT GHVRFLAAVQ
  1981  LPDGFNLLCP TPPPPPDTGP EKLPSLEHRD SPWHRGPAPA RPKMLVISGG DGYEDFRLSS
  2041  GGGSSSETVG RDDSTNHLLL WRV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARHGEF17 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 107 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 107 nTPM
cerebellum: 54 nTPM
cervix: 48 nTPM
colon: 47 nTPM
endometrium: 45 nTPM
heart muscle: 45 nTPM

Single-cell type

pericytes: 177 nCPM
vascular smooth muscle cells: 134 nCPM
podocytes: 80 nCPM
retinal amacrine cells: 67 nCPM
endometrial stromal cells: 63 nCPM
astrocytes: 62 nCPM

Immune cell

plasmacytoid DC: 0.2 nTPM
myeloid DC: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

cerebral cortex: 100 nTPM
basal ganglia: 88 nTPM
pons: 86 nTPM
hypothalamus: 84 nTPM
medulla oblongata: 83 nTPM
thalamus: 79 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.29
gnomAD pLI: 0.98
gnomAD missense Z: 0.75
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

guanyl-nucleotide exchange factor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARHGEF17 as an antibody target. Whether an autoantibody or antibody against ARHGEF17 could matter depends on whether native ARHGEF17 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARHGEF17 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ARHGEF17 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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