Seroatlas · Human Serome Atlas

FGD6

FYVE, RhoGEF and PH domain-containing protein 6

Also known as: FGD6_HUMAN, FLJ11183, ZFYVE24

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZV73
Gene: FGD6
Ensembl: ENSG00000180263
Chromosome: 12
Canonical length: 1430 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to be involved in actin cytoskeleton organization; filopodium assembly; and regulation of cell shape. Predicted to be located in Golgi apparatus; lamellipodium; and ruffle. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1430 residues, UniProt reviewed canonical sequence.

>Q6ZV73|FGD6
     1  MTSAAEIKKP PVAPKPKFVV ANNKPAPPPI APKPDIVISS VPQSTKKMKP AIAPKPKVLK
    61  TSPVREIGQS PSRKIMLNLE GHKQELAEST DNFNCKYEGN QSNDYISPMC SCSSECIHKL
   121  GHRENLCVKQ LVLEPLEMNE NLENSKIDET LTIKTRSKCD LYGEKAKNQG GVVLKASVLE
   181  EELKDALIHQ MPPFISAQKH RPTDSPEMNG GCNSNGQFRI EFADLSPSPS SFEKVPDHHS
   241  CHLQLPSDEC EHFETCQDDS EKSNNCFQSS ELEALENGKR STLISSDGVS KKSEVKDLGP
   301  LEIHLVPYTP KFPTPKPRKT RTARLLRQKC VDTPSESTEE PGNSDSSSSC LTENSLKINK
   361  ISVLHQNVLC KQEQVDKMKL GNKSELNMES NSDAQDLVNS QKAMCNETTS FEKMAPSFDK
   421  DSNLSSDSTT VDGSSMSLAV DEGTGFIRCT VSMSLPKQLK LTCNEHLQSG RNLGVSAPQM
   481  QKESVIKEEN SLRIVPKKPQ RHSLPATGVL KKAASEELLE KSSYPSSEEK SSEKSLERNH
   541  LQHLCAQNRG VSSSFDMPKR ASEKPVWKLP HPILPFSGNP EFLKSVTVSS NSEPSTALTK
   601  PRAKSLSAMD VEKCTKPCKD STKKNSFKKL LSMKLSICFM KSDFQKFWSK SSQLGDTTTG
   661  HLSSGEQKGI ESDWQGLLVG EEKRSKPIKA YSTENYSLES QKKRKKSRGQ TSAANGLRAE
   721  SLDDQMLSRE SSSQAPYKSV TSLCAPEYEN IRHYEEIPEY ENLPFIMAIR KTQELEWQNS
   781  SSMEDADANV YEVEEPYEAP DGQLQLGPRH QHSSSGASQE EQNDLGLGDL PSDEEEIINS
   841  SDEDDVSSES SKGEPDPLED KQDEDNGMKS KVHHIAKEIM SSEKVFVDVL KLLHIDFRDA
   901  VAHASRQLGK PVIEDRILNQ ILYYLPQLYE LNRDLLKELE ERMLHWTEQQ RIADIFVKKG
   961  PYLKMYSTYI KEFDKNIALL DEQCKKNPGF AAVVREFEMS PRCANLALKH YLLKPVQRIP
  1021  QYRLLLTDYL KNLIEDAGDY RDTQDALAVV IEVANHANDT MKQGDNFQKL MQIQYSLNGH
  1081  HEIVQPGRVF LKEGILMKLS RKVMQPRMFF LFNDALLYTT PVQSGMYKLN NMLSLAGMKV
  1141  RKPTQEAYQN ELKIESVERS FILSASSATE RDEWLEAISR AIEEYAKKRI TFCPSRSLDE
  1201  ADSENKEEVS PLGSKAPIWI PDTRATMCMI CTSEFTLTWR RHHCRACGKI VCQACSSNKY
  1261  GLDYLKNQPA RVCEHCFQEL QKLDHQHSPR IGSPGNHKSP SSALSSVLHS IPSGRKQKKI
  1321  PAALKEVSAN TEDSSMSGYL YRSKGNKKPW KHFWFVIKNK VLYTYAASED VAALESQPLL
  1381  GFTVIQVKDE NSESKVFQLL HKNMLFYVFK AEDAHSAQKW IEAFQEGTIL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FGD6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 9.1 nTPM

Expression across tissuesHPA

Tissue

tonsil: 9.1 nTPM
skin: 7.4 nTPM
lymph node: 5.1 nTPM
lung: 4.9 nTPM
appendix: 4.8 nTPM
thyroid gland: 4.8 nTPM

Single-cell type

syncytiotrophoblasts: 246 nCPM
basal keratinocytes: 212 nCPM
endometrial glandular cells: 155 nCPM
astrocytes: 134 nCPM
ocular epithelial cells: 132 nCPM
respiratory ionocytes: 130 nCPM

Immune cell

intermediate monocyte: 2.5 nTPM
non-classical monocyte: 2 nTPM
classical monocyte: 1.6 nTPM
naive B-cell: 1.5 nTPM
myeloid DC: 0.9 nTPM
total PBMC: 0.6 nTPM

Brain region

cerebral cortex: 23 nTPM
basal ganglia: 23 nTPM
choroid plexus: 21 nTPM
amygdala: 19 nTPM
hippocampal formation: 19 nTPM
thalamus: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.54
gnomAD pLI: 0
gnomAD missense Z: 0.97
DepMap mean gene effect: -0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FGD6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FGD6 as an antibody target. Whether an autoantibody or antibody against FGD6 could matter depends on whether native FGD6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FGD6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FGD6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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