Seroatlas · Human Serome Atlas

FARP2

FERM, ARHGEF and pleckstrin domain-containing protein 2

Also known as: FARP2_HUMAN, FIR, FRG, KIAA0793, PLEKHC3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O94887
Gene
FARP2
Ensembl
ENSG00000006607
Chromosome
2
Canonical length
1054 aa
Protein class
Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

Enables guanyl-nucleotide exchange factor activity. Acts upstream of or within Rac protein signal transduction and neuron remodeling. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1054 residues, UniProt reviewed canonical sequence.

>O94887|FARP2
     1  MGEIEGTYRV LQTAGMRLGA QTPVGVSTLE PGQTLLPRMQ EKHLHLRVKL LDNTMEIFDI
    61  EPKCDGQVLL TQVWKRLNLV ECDYFGMEFQ NTQSYWIWLE PMKPIIRQIR RPKNVVLRLA
   121  VKFFPPDPGQ LQEEYTRYLF ALQLKRDLLE ERLTCADTTA ALLTSHLLQS EIGDYDETLD
   181  REHLKVNEYL PGQQHCLEKI LEFHQKHVGQ TPAESDFQVL EIARKLEMYG IRFHMASDRE
   241  GTKIQLAVSH MGVLVFQGTT KINTFNWSKV RKLSFKRKRF LIKLHPEVHG PYQDTLEFLL
   301  GSRDECKNFW KICVEYHTFF RLLDQPKPKA KAVFFSRGSS FRYSGRTQKQ LVDYFKDSGM
   361  KRIPYERRHS KTHTSVRALT ADLPKQSISF PEGLRTPASP SSANAFYSLS PSTLVPSGLP
   421  EFKDSSSSLT DPQVSYVKSP AAERRSGAVA GGPDTPSAQP LGPPALQPGP GLSTKSPQPS
   481  PSSRKSPLSL SPAFQVPLGP AEQGSSPLLS PVLSDAGGAG MDCEEPRHKR VPADEAYFIV
   541  KEILATERTY LKDLEVITVW FRSAVVKEDA MPATLMTLLF SNIDPIYEFH RGFLREVEQR
   601  LALWEGPSKA HTKGSHQRIG DILLRNMRQL KEFTSYFQRH DEVLTELEKA TKRCKKLEAV
   661  YKEFELQKVC YLPLNTFLLK PIQRLLHYRL LLRRLCGHYS PGHHDYADCH DALKAITEVT
   721  TTLQHILIRL ENLQKLTELQ RDLVGIENLI APGREFIREG CLHKLTKKGL QQRMFFLFSD
   781  MLLYTSKGVA GTSHFRIRGL LPLQGMLVEE SDNEWSVPHC FTIYAAQKTI VVAASTRLEK
   841  EKWMLDLNSA IQAAKSGGDT APALPGRTVC TRPPRSPNEV SLEQESEDDA RGVRSSLEGH
   901  GQHRANTTMH VCWYRNTSVS RADHSAAVEN QLSGYLLRKF KNSHGWQKLW VVFTNFCLFF
   961  YKTHQDDYPL ASLPLLGYSV SIPREADGIH KDYVFKLQFK SHVYFFRAES KYTFERWMEV
  1021  IQGASSSAGR APSIVQDGPQ PSSGLEGMVR GKEE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FARP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
27 nTPM

Expression across tissuesHPA

Tissue

  • testis: 27 nTPM
  • skin: 22 nTPM
  • cerebellum: 21 nTPM
  • colon: 21 nTPM
  • rectum: 20 nTPM
  • stomach: 19 nTPM

Single-cell type

  • melanocytes: 300 nCPM
  • early primary spermatocytes: 240 nCPM
  • urothelial cells: 191 nCPM
  • goblet cells: 190 nCPM
  • b-cells: 182 nCPM
  • mast cells: 173 nCPM

Immune cell

  • eosinophil: 7.4 nTPM
  • plasmacytoid DC: 6.4 nTPM
  • basophil: 6.2 nTPM
  • intermediate monocyte: 5.1 nTPM
  • naive B-cell: 4.9 nTPM
  • memory B-cell: 4.4 nTPM

Brain region

  • white matter: 43 nTPM
  • cerebellum: 40 nTPM
  • basal ganglia: 35 nTPM
  • thalamus: 34 nTPM
  • medulla oblongata: 33 nTPM
  • pons: 33 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.18
gnomAD pLI
0
gnomAD missense Z
-0.33
DepMap mean gene effect
0.04
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FARP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FARP2 as an antibody target. Whether an autoantibody or antibody against FARP2 could matter depends on whether native FARP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FARP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FARP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FARP2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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