Seroatlas · Human Serome Atlas

RPS8

Small ribosomal subunit protein eS8

Also known as: RS8_HUMAN, S8

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P62241
Gene
RPS8
Ensembl
ENSG00000142937
Chromosome
1
Canonical length
208 aa
Protein class
Plasma proteins, Predicted intracellular proteins, Ribosomal proteins
Subcellular location
Endoplasmic reticulum,Cytosol

OverviewNCBI Gene

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S8E family of ribosomal proteins. It is located in the cytoplasm. Increased expression of this gene in colorectal tumors and colon polyps compared to matched normal colonic mucosa has been observed. This gene is co-transcribed with the small nucleolar RNA genes U38A, U38B, U39, and U40, which are located in its fourth, fifth, first, and second introns, respectively. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

208 residues, UniProt reviewed canonical sequence.

>P62241|RPS8
     1  MGISRDNWHK RRKTGGKRKP YHKKRKYELG RPAANTKIGP RRIHTVRVRG GNKKYRALRL
    61  DVGNFSWGSE CCTRKTRIID VVYNASNNEL VRTKTLVKNC IVLIDSTPYR QWYESHYALP
   121  LGRKKGAKLT PEEEEILNKK RSKKIQKKYD ERKKNAKISS LLEEQFQQGK LLACIASRPG
   181  QCGRADGYVL EGKELEFYLR KIKARKGK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPS8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.35
Highest tissue expression
5,675 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 5,675 nTPM
  • bone marrow: 3,286 nTPM
  • pancreas: 2,950 nTPM
  • skin: 2,903 nTPM
  • cervix: 2,651 nTPM
  • esophagus: 2,538 nTPM

Single-cell type

  • esophageal suprabasal cells: 11,650 nCPM
  • ovarian stromal cells: 11,343 nCPM
  • decidual stromal cells: 11,327 nCPM
  • esophageal apical cells: 11,170 nCPM
  • esophageal basal cells: 9,581 nCPM
  • suprabasal keratinocytes: 9,376 nCPM

Immune cell

  • total PBMC: 3,326 nTPM
  • memory B-cell: 2,317 nTPM
  • naive B-cell: 1,951 nTPM
  • naive CD4 T-cell: 1,862 nTPM
  • naive CD8 T-cell: 1,603 nTPM
  • plasmacytoid DC: 1,558 nTPM

Brain region

  • spinal cord: 582 nTPM
  • white matter: 568 nTPM
  • medulla oblongata: 504 nTPM
  • thalamus: 459 nTPM
  • basal ganglia: 448 nTPM
  • hypothalamus: 448 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.22
gnomAD pLI
0.99
gnomAD missense Z
2.42
DepMap mean gene effect
-2.88
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RPS8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RPS8 as an antibody target. Whether an autoantibody or antibody against RPS8 could matter depends on whether native RPS8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RPS8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RPS8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RPS8. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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