Seroatlas · Human Serome Atlas

RPL31

Large ribosomal subunit protein eL31

Also known as: L31, RL31_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P62899
Gene: RPL31
Ensembl: ENSG00000071082
Chromosome: 2
Canonical length: 125 aa
Protein class: Plasma proteins, Predicted intracellular proteins, Ribosomal proteins

OverviewNCBI Gene

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L31E family of ribosomal proteins. It is located in the cytoplasm. Higher levels of expression of this gene in familial adenomatous polyps compared to matched normal tissues have been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

125 residues, UniProt reviewed canonical sequence.

>P62899|RPL31
     1  MAPAKKGGEK KKGRSAINEV VTREYTINIH KRIHGVGFKK RAPRALKEIR KFAMKEMGTP
    61  DVRIDTRLNK AVWAKGIRNV PYRIRVRLSR KRNEDEDSPN KLYTLVTYVP VTTFKNLQTV
   121  NVDEN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPL31 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 5,785 nTPM

Expression across tissuesHPA

Tissue

ovary: 5,785 nTPM
bone marrow: 4,006 nTPM
pancreas: 3,499 nTPM
cervix: 3,234 nTPM
skin: 3,109 nTPM
amygdala: 3,062 nTPM

Single-cell type

decidual stromal cells: 7,456 nCPM
ovarian stromal cells: 6,950 nCPM
esophageal suprabasal cells: 6,393 nCPM
esophageal apical cells: 5,696 nCPM
extravillous trophoblasts: 5,671 nCPM
epididymal efferent duct absorptive cells: 5,581 nCPM

Immune cell

total PBMC: 14,498 nTPM
naive CD4 T-cell: 10,671 nTPM
naive CD8 T-cell: 8,809 nTPM
memory B-cell: 8,507 nTPM
memory CD4 T-cell: 7,832 nTPM
MAIT T-cell: 7,250 nTPM

Brain region

thalamus: 683 nTPM
spinal cord: 642 nTPM
white matter: 617 nTPM
basal ganglia: 607 nTPM
cerebral cortex: 584 nTPM
amygdala: 578 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RPL31.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 79 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Diamond-Blackfan anemia

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.48
gnomAD pLI: 0.85
gnomAD missense Z: 1.64
DepMap mean gene effect: -2.54
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Large ribosomal subunit protein eL31
Large ribosomal subunit protein eL31, conserved site
Large ribosomal subunit protein eL31 domain superfamily
Ribosomal protein L31e

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RPL31 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RPL31 as an antibody target. Whether an autoantibody or antibody against RPL31 could matter depends on whether native RPL31 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RPL31 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RPL31 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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