Seroatlas · Human Serome Atlas

SIRT6

NAD-dependent protein deacylase sirtuin-6

Also known as: SIR6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8N6T7
Gene
SIRT6
Ensembl
ENSG00000077463
Chromosome
19
Canonical length
355 aa
Protein class
Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Vesicles
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a member of the sirtuin family of NAD-dependent enzymes that are implicated in cellular stress resistance, genomic stability, aging and energy homeostasis. The encoded protein is localized to the nucleus, exhibits ADP-ribosyl transferase and histone deacetylase activities, and plays a role in DNA repair, maintenance of telomeric chromatin, inflammation, lipid and glucose metabolism. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]

Canonical amino-acid sequenceUniProt

355 residues, UniProt reviewed canonical sequence.

>Q8N6T7|SIRT6
     1  MSVNYAAGLS PYADKGKCGL PEIFDPPEEL ERKVWELARL VWQSSSVVFH TGAGISTASG
    61  IPDFRGPHGV WTMEERGLAP KFDTTFESAR PTQTHMALVQ LERVGLLRFL VSQNVDGLHV
   121  RSGFPRDKLA ELHGNMFVEE CAKCKTQYVR DTVVGTMGLK ATGRLCTVAK ARGLRACRGE
   181  LRDTILDWED SLPDRDLALA DEASRNADLS ITLGTSLQIR PSGNLPLATK RRGGRLVIVN
   241  LQPTKHDRHA DLRIHGYVDE VMTRLMKHLG LEIPAWDGPR VLERALPPLP RPPTPKLEPK
   301  EESPTRINGS IPAGPKQEPC AQHNGSEPAS PKRERPTSPA PHRPPKRVKA KAVPS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SIRT6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
24 nTPM

Expression across tissuesHPA

Tissue

  • colon: 24 nTPM
  • cerebellum: 16 nTPM
  • spleen: 16 nTPM
  • pancreas: 15 nTPM
  • small intestine: 14 nTPM
  • pituitary gland: 14 nTPM

Single-cell type

  • colonocytes: 262 nCPM
  • goblet cells: 59 nCPM
  • enterocytes: 53 nCPM
  • syncytiotrophoblasts: 47 nCPM
  • enteric transient amplifying cells: 47 nCPM
  • extravillous trophoblasts: 41 nCPM

Immune cell

  • intermediate monocyte: 16 nTPM
  • myeloid DC: 14 nTPM
  • non-classical monocyte: 14 nTPM
  • classical monocyte: 13 nTPM
  • T-reg: 13 nTPM
  • eosinophil: 12 nTPM

Brain region

  • cerebral cortex: 16 nTPM
  • thalamus: 15 nTPM
  • medulla oblongata: 12 nTPM
  • basal ganglia: 11 nTPM
  • pons: 11 nTPM
  • amygdala: 11 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SIRT6.

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 89 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.7
gnomAD pLI
0.04
gnomAD missense Z
0.61
DepMap mean gene effect
0.11
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SIRT6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SIRT6 as an antibody target. Whether an autoantibody or antibody against SIRT6 could matter depends on whether native SIRT6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SIRT6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SIRT6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SIRT6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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