Seroatlas · Human Serome Atlas

SERBP1

SERPINE1 mRNA-binding protein 1

Also known as: CGI-55, CHD3IP, DKFZP564M2423, HABP4L, PAI-RBP1, PAIRBP1, SERB1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NC51
Gene: SERBP1
Ensembl: ENSG00000142864
Chromosome: 1
Canonical length: 408 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Enables several functions, including SUMO binding activity; mRNA 3'-UTR binding activity; and ribosome binding activity. Involved in PML body organization and ribosome hibernation. Located in cytosol and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

408 residues, UniProt reviewed canonical sequence.

>Q8NC51|SERBP1
     1  MPGHLQEGFG CVVTNRFDQL FDDESDPFEV LKAAENKKKE AGGGGVGGPG AKSAAQAAAQ
    61  TNSNAAGKQL RKESQKDRKN PLPPSVGVVD KKEETQPPVA LKKEGIRRVG RRPDQQLQGE
   121  GKIIDRRPER RPPRERRFEK PLEEKGEGGE FSVDRPIIDR PIRGRGGLGR GRGGRGRGMG
   181  RGDGFDSRGK REFDRHSGSD RSSFSHYSGL KHEDKRGGSG SHNWGTVKDE LTESPKYIQK
   241  QISYNYSDLD QSNVTEETPE GEEHHPVADT ENKENEVEEV KEEGPKEMTL DEWKAIQNKD
   301  RAKVEFNIRK PNEGADGQWK KGFVLHKSKS EEAHAEDSVM DHHFRKPAND ITSQLEINFG
   361  DLGRPGRGGR GGRGGRGRGG RPNRGSRTDK SSASAPDVDD PEAFPALA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SERBP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.68
Highest tissue expression: 316 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 316 nTPM
esophagus: 163 nTPM
tongue: 149 nTPM
skin: 131 nTPM
parathyroid gland: 124 nTPM
bone marrow: 123 nTPM

Single-cell type

esophageal basal cells: 872 nCPM
late primary spermatocytes: 863 nCPM
erythrocyte progenitors: 863 nCPM
esophageal suprabasal cells: 842 nCPM
suprabasal keratinocytes: 830 nCPM
basal keratinocytes: 767 nCPM

Immune cell

NK-cell: 148 nTPM
T-reg: 132 nTPM
MAIT T-cell: 126 nTPM
total PBMC: 119 nTPM
naive CD4 T-cell: 115 nTPM
myeloid DC: 108 nTPM

Brain region

medulla oblongata: 91 nTPM
white matter: 90 nTPM
spinal cord: 89 nTPM
thalamus: 88 nTPM
pons: 85 nTPM
basal ganglia: 83 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.18
gnomAD pLI: 1
gnomAD missense Z: 1.67
DepMap mean gene effect: -0.54
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SERBP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SERBP1 as an antibody target. Whether an autoantibody or antibody against SERBP1 could matter depends on whether native SERBP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SERBP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SERBP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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