Seroatlas · Human Serome Atlas

RPS24

Small ribosomal subunit protein eS24

Also known as: eS24, RS24_HUMAN, S24

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P62847
Gene
RPS24
Ensembl
ENSG00000138326
Chromosome
10
Canonical length
133 aa
Protein class
Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Ribosomal proteins
Subcellular location
Endoplasmic reticulum,Cytosol

OverviewNCBI Gene

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S24E family of ribosomal proteins. It is located in the cytoplasm. Multiple transcript variants encoding different isoforms have been found for this gene. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Mutations in this gene result in Diamond-Blackfan anemia. [provided by RefSeq, Nov 2008]

Canonical amino-acid sequenceUniProt

133 residues, UniProt reviewed canonical sequence.

>P62847|RPS24
     1  MNDTVTIRTR KFMTNRLLQR KQMVIDVLHP GKATVPKTEI REKLAKMYKT TPDVIFVFGF
    61  RTHFGGGKTT GFGMIYDSLD YAKKNEPKHR LARHGLYEKK KTSRKQRKER KNRMKKVRGT
   121  AKANVGAGKK PKE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPS24 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.4
Highest tissue expression
6,132 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 6,132 nTPM
  • breast: 4,439 nTPM
  • bone marrow: 4,405 nTPM
  • skeletal muscle: 3,587 nTPM
  • pancreas: 3,409 nTPM
  • cervix: 3,328 nTPM

Single-cell type

  • esophageal suprabasal cells: 8,920 nCPM
  • late spermatids: 7,787 nCPM
  • esophageal apical cells: 7,300 nCPM
  • decidual stromal cells: 7,286 nCPM
  • ovarian stromal cells: 7,253 nCPM
  • extravillous trophoblasts: 7,251 nCPM

Immune cell

  • total PBMC: 4,394 nTPM
  • myeloid DC: 2,937 nTPM
  • naive CD4 T-cell: 2,871 nTPM
  • NK-cell: 2,808 nTPM
  • memory B-cell: 2,808 nTPM
  • naive CD8 T-cell: 2,653 nTPM

Brain region

  • hypothalamus: 767 nTPM
  • white matter: 706 nTPM
  • spinal cord: 665 nTPM
  • medulla oblongata: 649 nTPM
  • pons: 623 nTPM
  • cerebral cortex: 592 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RPS24.

Disease | AllUniProt

Conditions RPS24 is implicated in, by any mechanism.

Disease | GeneticClinVar

17 pathogenic / likely-pathogenic of 235 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.59
gnomAD pLI
0.68
gnomAD missense Z
1.16
DepMap mean gene effect
-1.71
DepMap dependency class
pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RPS24 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RPS24 as an antibody target. Whether an autoantibody or antibody against RPS24 could matter depends on whether native RPS24 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RPS24 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RPS24 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RPS24. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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