Seroatlas · Human Serome Atlas

RPTOR

Regulatory-associated protein of mTOR

Also known as: KIAA1303, KOG1, Mip1, raptor, RPTOR_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N122
Gene: RPTOR
Ensembl: ENSG00000141564
Chromosome: 17
Canonical length: 1335 aa
Protein class: Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Vesicles,Lysosomes,Cytosol

OverviewNCBI Gene

This gene encodes a component of a signaling pathway that regulates cell growth in response to nutrient and insulin levels. The encoded protein forms a stoichiometric complex with the mTOR kinase, and also associates with eukaryotic initiation factor 4E-binding protein-1 and ribosomal protein S6 kinase. The protein positively regulates the downstream effector ribosomal protein S6 kinase, and negatively regulates the mTOR kinase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Canonical amino-acid sequenceUniProt

1335 residues, UniProt reviewed canonical sequence.

>Q8N122|RPTOR
     1  MESEMLQSPL LGLGEEDEAD LTDWNLPLAF MKKRHCEKIE GSKSLAQSWR MKDRMKTVSV
    61  ALVLCLNVGV DPPDVVKTTP CARLECWIDP LSMGPQKALE TIGANLQKQY ENWQPRARYK
   121  QSLDPTVDEV KKLCTSLRRN AKEERVLFHY NGHGVPRPTV NGEVWVFNKN YTQYIPLSIY
   181  DLQTWMGSPS IFVYDCSNAG LIVKSFKQFA LQREQELEVA AINPNHPLAQ MPLPPSMKNC
   241  IQLAACEATE LLPMIPDLPA DLFTSCLTTP IKIALRWFCM QKCVSLVPGV TLDLIEKIPG
   301  RLNDRRTPLG ELNWIFTAIT DTIAWNVLPR DLFQKLFRQD LLVASLFRNF LLAERIMRSY
   361  NCTPVSSPRL PPTYMHAMWQ AWDLAVDICL SQLPTIIEEG TAFRHSPFFA EQLTAFQVWL
   421  TMGVENRNPP EQLPIVLQVL LSQVHRLRAL DLLGRFLDLG PWAVSLALSV GIFPYVLKLL
   481  QSSARELRPL LVFIWAKILA VDSSCQADLV KDNGHKYFLS VLADPYMPAE HRTMTAFILA
   541  VIVNSYHTGQ EACLQGNLIA ICLEQLNDPH PLLRQWVAIC LGRIWQNFDS ARWCGVRDSA
   601  HEKLYSLLSD PIPEVRCAAV FALGTFVGNS AERTDHSTTI DHNVAMMLAQ LVSDGSPMVR
   661  KELVVALSHL VVQYESNFCT VALQFIEEEK NYALPSPATT EGGSLTPVRD SPCTPRLRSV
   721  SSYGNIRAVA TARSLNKSLQ NLSLTEESGG AVAFSPGNLS TSSSASSTLG SPENEEHILS
   781  FETIDKMRRA SSYSSLNSLI GVSFNSVYTQ IWRVLLHLAA DPYPEVSDVA MKVLNSIAYK
   841  ATVNARPQRV LDTSSLTQSA PASPTNKGVH IHQAGGSPPA SSTSSSSLTN DVAKQPVSRD
   901  LPSGRPGTTG PAGAQYTPHS HQFPRTRKMF DKGPEQTADD ADDAAGHKSF ISATVQTGFC
   961  DWSARYFAQP VMKIPEEHDL ESQIRKEREW RFLRNSRVRR QAQQVIQKGI TRLDDQIFLN
  1021  RNPGVPSVVK FHPFTPCIAV ADKDSICFWD WEKGEKLDYF HNGNPRYTRV TAMEYLNGQD
  1081  CSLLLTATDD GAIRVWKNFA DLEKNPEMVT AWQGLSDMLP TTRGAGMVVD WEQETGLLMS
  1141  SGDVRIVRIW DTDREMKVQD IPTGADSCVT SLSCDSHRSL IVAGLGDGSI RVYDRRMALS
  1201  ECRVMTYREH TAWVVKASLQ KRPDGHIVSV SVNGDVRIFD PRMPESVNVL QIVKGLTALD
  1261  IHPQADLIAC GSVNQFTAIY NSSGELINNI KYYDGFMGQR VGAISCLAFH PHWPHLAVGS
  1321  NDYYISVYSV EKRVR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPTOR can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 13 nTPM
cerebral cortex: 6.7 nTPM
blood vessel: 6.6 nTPM
tongue: 6.5 nTPM
urinary bladder: 6.3 nTPM
endometrium: 6.2 nTPM

Single-cell type

thymic myoid cells: 345 nCPM
myonuclei: 283 nCPM
somatotrophs: 215 nCPM
lactotrophs: 200 nCPM
cone photoreceptor cells: 178 nCPM
renal collecting duct intercalated cells: 173 nCPM

Immune cell

T-reg: 1 nTPM
gdT-cell: 0.6 nTPM
myeloid DC: 0.4 nTPM
intermediate monocyte: 0.3 nTPM
MAIT T-cell: 0.3 nTPM
memory CD8 T-cell: 0.3 nTPM

Brain region

cerebral cortex: 24 nTPM
hippocampal formation: 24 nTPM
amygdala: 23 nTPM
thalamus: 23 nTPM
pons: 22 nTPM
medulla oblongata: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.1
gnomAD pLI: 1
gnomAD missense Z: 4.94
DepMap mean gene effect: -0.91
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

HEAT repeat
WD40 repeat
Armadillo-like helical
WD40/YVTN repeat-like-containing domain superfamily
Armadillo-type fold
WD40-repeat-containing domain superfamily
WD domain, G-beta repeat
HEAT repeat
Regulatory associated protein of TOR
Raptor, N-terminal CASPase-like domain
Raptor N-terminal CASPase like domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RPTOR in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RPTOR as an antibody target. Whether an autoantibody or antibody against RPTOR could matter depends on whether native RPTOR is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RPTOR is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RPTOR as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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