Seroatlas · Human Serome Atlas

CAPRIN1

Caprin-1

Also known as: CAPR1_HUMAN, caprin-1, GPIAP1, M11S1, RNG105

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q14444
Gene
CAPRIN1
Ensembl
ENSG00000135387
Chromosome
11
Canonical length
709 aa
Protein class
Predicted intracellular proteins
Subcellular location
Cytosol
Quaternary structure
Homomultimer

OverviewNCBI Gene

Enables several functions, including ATP binding activity; molecular condensate scaffold activity; and signaling adaptor activity. Involved in membraneless organelle assembly; positive regulation of stress granule assembly; and regulation of gene expression. Located in cell leading edge and cytosol. Is active in intracellular membraneless organelle. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

709 residues, UniProt reviewed canonical sequence.

>Q14444|CAPRIN1
     1  MPSATSHSGS GSKSSGPPPP SGSSGSEAAA GAGAAAPASQ HPATGTGAVQ TEAMKQILGV
    61  IDKKLRNLEK KKGKLDDYQE RMNKGERLNQ DQLDAVSKYQ EVTNNLEFAK ELQRSFMALS
   121  QDIQKTIKKT ARREQLMREE AEQKRLKTVL ELQYVLDKLG DDEVRTDLKQ GLNGVPILSE
   181  EELSLLDEFY KLVDPERDMS LRLNEQYEHA SIHLWDLLEG KEKPVCGTTY KVLKEIVERV
   241  FQSNYFDSTH NHQNGLCEEE EAASAPAVED QVPEAEPEPA EEYTEQSEVE STEYVNRQFM
   301  AETQFTSGEK EQVDEWTVET VEVVNSLQQQ PQAASPSVPE PHSLTPVAQA DPLVRRQRVQ
   361  DLMAQMQGPY NFIQDSMLDF ENQTLDPAIV SAQPMNPTQN MDMPQLVCPP VHSESRLAQP
   421  NQVPVQPEAT QVPLVSSTSE GYTASQPLYQ PSHATEQRPQ KEPIDQIQAT ISLNTDQTTA
   481  SSSLPAASQP QVFQAGTSKP LHSSGINVNA APFQSMQTVF NMNAPVPPVN EPETLKQQNQ
   541  YQASYNQSFS SQPHQVEQTE LQQEQLQTVV GTYHGSPDQS HQVTGNHQQP PQQNTGFPRS
   601  NQPYYNSRGV SRGGSRGARG LMNGYRGPAN GFRGGYDGYR PSFSNTPNSG YTQSQFSAPR
   661  DYSGYQRDGY QQNFKRGSGQ SGPRGAPRGR GGPPRPNRGM PQMNTQQVN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CAPRIN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.61
Highest tissue expression
115 nTPM

Expression across tissuesHPA

Tissue

  • testis: 115 nTPM
  • thymus: 72 nTPM
  • bone marrow: 66 nTPM
  • smooth muscle: 62 nTPM
  • tonsil: 59 nTPM
  • fallopian tube: 58 nTPM

Single-cell type

  • late primary spermatocytes: 511 nCPM
  • early spermatids: 505 nCPM
  • late spermatids: 367 nCPM
  • megakaryocyte progenitors: 193 nCPM
  • erythrocyte progenitors: 188 nCPM
  • endometrial glandular cells: 181 nCPM

Immune cell

  • non-classical monocyte: 44 nTPM
  • intermediate monocyte: 40 nTPM
  • myeloid DC: 39 nTPM
  • classical monocyte: 33 nTPM
  • total PBMC: 31 nTPM
  • NK-cell: 31 nTPM

Brain region

  • white matter: 126 nTPM
  • spinal cord: 116 nTPM
  • cerebral cortex: 108 nTPM
  • hypothalamus: 108 nTPM
  • hippocampal formation: 108 nTPM
  • medulla oblongata: 108 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CAPRIN1.

Disease | AllUniProt

Conditions CAPRIN1 is implicated in, by any mechanism.

  • Neurodegeneration, childhood-onset, with cerebellar ataxia and cognitive decline (CONDCAC) MIM:620636
  • Neurodevelopmental disorder with language impairment, autism, and attention deficit-hyperactivity disorder (NEDLAAD) MIM:620782

Disease | GeneticClinVar

30 pathogenic / likely-pathogenic of 186 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.31
gnomAD pLI
0.97
gnomAD missense Z
1.69
DepMap mean gene effect
0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CAPRIN1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CAPRIN1 as an antibody target. Whether an autoantibody or antibody against CAPRIN1 could matter depends on whether native CAPRIN1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CAPRIN1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CAPRIN1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CAPRIN1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...