Seroatlas · Human Serome Atlas

RPS23

Small ribosomal subunit protein uS12

Also known as: RS23_HUMAN, S23, uS12

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P62266
Gene: RPS23
Ensembl: ENSG00000186468
Chromosome: 5
Canonical length: 143 aa
Protein class: Disease related genes, Predicted intracellular proteins, Ribosomal proteins
Subcellular location: Endoplasmic reticulum,Cytosol

OverviewNCBI Gene

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S12P family of ribosomal proteins. It is located in the cytoplasm. The protein shares significant amino acid similarity with S. cerevisiae ribosomal protein S28. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

143 residues, UniProt reviewed canonical sequence.

>P62266|RPS23
     1  MGKCRGLRTA RKLRSHRRDQ KWHDKQYKKA HLGTALKANP FGGASHAKGI VLEKVGVEAK
    61  QPNSAIRKCV RVQLIKNGKK ITAFVPNDGC LNFIEENDEV LVAGFGRKGH AVGDIPGVRF
   121  KVVKVANVSL LALYKGKKER PRS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPS23 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 4,098 nTPM

Expression across tissuesHPA

Tissue

ovary: 4,098 nTPM
skeletal muscle: 2,725 nTPM
thymus: 2,508 nTPM
breast: 2,470 nTPM
choroid plexus: 2,366 nTPM
tonsil: 2,350 nTPM

Single-cell type

esophageal suprabasal cells: 8,104 nCPM
esophageal basal cells: 7,464 nCPM
extravillous trophoblasts: 7,376 nCPM
ovarian stromal cells: 7,151 nCPM
decidual stromal cells: 6,833 nCPM
migrating cytotrophoblasts: 6,653 nCPM

Immune cell

total PBMC: 2,818 nTPM
memory B-cell: 1,954 nTPM
naive B-cell: 1,745 nTPM
naive CD4 T-cell: 1,738 nTPM
plasmacytoid DC: 1,546 nTPM
naive CD8 T-cell: 1,500 nTPM

Brain region

spinal cord: 475 nTPM
white matter: 432 nTPM
thalamus: 427 nTPM
choroid plexus: 391 nTPM
medulla oblongata: 391 nTPM
basal ganglia: 389 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RPS23.

Disease | AllUniProt

Conditions RPS23 is implicated in, by any mechanism.

Brachycephaly, trichomegaly, and developmental delay (BTDD) MIM:617412

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 24 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Brachycephaly, trichomegaly, and developmental delay

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.47
gnomAD pLI: 0.86
gnomAD missense Z: 2.36
DepMap mean gene effect: -2.33
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Small ribosomal subunit protein uS12
Nucleic acid-binding, OB-fold
Ribosomal protein S12/S23
Small ribosomal subunit protein uS12, eukaryota/archaea

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RPS23 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RPS23 as an antibody target. Whether an autoantibody or antibody against RPS23 could matter depends on whether native RPS23 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RPS23 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RPS23 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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